Cheng Kevin, Webb E William, Bowden Gregory D, Wright Jay S, Shao Xia, Sanford Melanie S, Scott Peter J H
Department of Radiology, University of Michigan Medical School, 1301 Catherine Street, Ann Arbor, Michigan 48109, United States.
Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, 72074 Tuebingen, Germany.
Org Lett. 2024 Apr 26;26(16):3419-3423. doi: 10.1021/acs.orglett.4c00929. Epub 2024 Apr 17.
We present a photo- and Cu-mediated C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.
我们报道了一种通过芳基自由基加成途径实现的光和铜介导的稳定（杂）芳基噻蒽鎓盐的C氰化反应。噻蒽鎓底物可通过C-H官能化轻松获得，并且该放射性氰化反应方案在温和条件下（<50°C，5分钟）进行，并且可以使用对现有放射化学设备的开源、易于获取的增强装置实现自动化。
