Wang Qing-Dong, Chen Xue, Wu Yuan-Shuai, Miao Chengping, Yang Jin-Ming, Shen Zhi-Liang
School of Pharmacy, Yancheng Teachers University, Yancheng, 224007, China.
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chem Asian J. 2025 May 15;20(10):e202401873. doi: 10.1002/asia.202401873. Epub 2025 Mar 12.
Diverse α-aryl α-carbonyl sulfoxonium ylides were efficiently synthesized in yields ranging from moderate to high via a palladium-catalyzed α-arylation of sulfoxonium ylides with aryl thianthrenium salts. The reactions proceeded smoothly via C-S and C-H bond functionalization, exhibiting broad substrate scope and good compatibility to various functionalities. In addition, the scale-up synthesis could be achieved, and the one-pot protocol commencing from the use of simple arene as the precursor of aryl thianthrenium salt could also be accomplished.
通过钯催化的硫鎓叶立德与芳基噻蒽盐的α-芳基化反应，高效合成了多种α-芳基α-羰基硫鎓叶立德，产率从中等到高。反应通过C-S和C-H键官能团化顺利进行，底物范围广泛，对各种官能团具有良好的兼容性。此外，还可以实现放大合成，并且也可以完成从使用简单芳烃作为芳基噻蒽盐前体开始的一锅法合成。
