Li Han-Xiao, Yu Zhi-Xiang
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Org Lett. 2024 Apr 26;26(16):3458-3462. doi: 10.1021/acs.orglett.4c01029. Epub 2024 Apr 17.
Current methods for arene hydrogenation generally need either harsh reaction conditions or complex catalyst preparation. Here we describe a mild and convenient protocol that only utilizes commercially available catalysts. Using [Rh(nbd)Cl] and Pd/C together as catalysts, arenes bearing various functional groups can be hydrogenated under 1 atm of H at room temperature. This arene hydrogenation can also be achieved using catalysts of [Rh(cod)Cl] and PtO, thus avoiding glovebox manipulations and simplifying the reaction procedure.
目前用于芳烃加氢的方法通常需要苛刻的反应条件或复杂的催化剂制备过程。在此，我们描述了一种温和且简便的方法，该方法仅使用市售催化剂。使用[Rh(nbd)Cl]和Pd/C共同作为催化剂，带有各种官能团的芳烃能够在室温、1个大气压氢气的条件下进行加氢反应。使用[Rh(cod)Cl]和PtO作为催化剂也可以实现这种芳烃加氢反应，从而避免了手套箱操作并简化了反应过程。
