海洋鱼类源真菌 Trichoderma sp. G13 中的抗炎单体琥泊酸衍生物
Anti-inflammatory monomeric sorbicillinoids from the marine-fish-derived fungus Trichoderma sp. G13.
机构信息
Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China; Drug Supply Department, Qingdao West Coast New Area Central Hospital, Shandong 266555, People's Republic of China.
Education and Science Office, School of Pharmacy, Qingdao University, Qingdao, Shandong 266071, People's Republic of China.
出版信息
Fitoterapia. 2024 Jun;175:105963. doi: 10.1016/j.fitote.2024.105963. Epub 2024 Apr 16.
Four new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC values ranging from 14 to 20 μM.
从海洋鱼类源真菌 Trichoderma sp. G13 中分离得到四个新的单体黏帚菌素类似物（1-4），以及两个已知的二聚体黏帚菌素类似物（5 和 6）和五个已知的单体黏帚菌素类似物（7-11）。基于全面的光谱研究（NMR、HRESIMS 和 ECD）对它们进行了结构表征。根据抑制 RAW264.7 细胞中 NO 的产生，化合物 1-4 显示出中等的抗炎活性，IC 值范围为 14-20 μM。
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