Xia Yan-Ping, Xie Yan, Rao Li, Yin Guo-Ping
Department of Pharmacy, Nanan People's Hospital of Chongqing, Chongqing, China.
Department of Pharmacy, Zhengzhou Shuqing Medical College, Zhengzhou, China.
Front Microbiol. 2025 Jan 28;16:1485032. doi: 10.3389/fmicb.2025.1485032. eCollection 2025.
Three new sorbicillinoid derivatives, citrinsorbicillinol A-C (-), along with three known compounds, such as trichosorbicillin G (), dibutyl phthalate (), and 3-(4-methoxyphenyl) propanoic acid (), were isolated from the endophyte of . Their structures were elucidated through extensive analyses of spectroscopic data, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations of the nuclear magnetic resonance (NMR) spectra, and electronic circular dichroism (ECD). Biologically, compounds - exhibited potential antioxidant activity, as assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, with IC values ranging from 27.8 to 89.6 μM. In particular, compounds and demonstrated radical scavenging activity comparable to that of the positive control, ascorbic acid, with IC values of 27.8 and 31.2 μM, respectively. Moreover, compound exhibited potential anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, with an IC value of 52.7 μM. These findings underscore the therapeutic potential of the new sorbicillinoid derivatives for antioxidant and anti-inflammatory applications.
从[植物名称]的内生菌中分离出三种新的山梨素类衍生物，柠檬山梨素醇A - C（-），以及三种已知化合物，如曲霉菌山梨素G（）、邻苯二甲酸二丁酯（）和3 -（4 - 甲氧基苯基）丙酸（）。通过对光谱数据的广泛分析、计算机辅助结构解析（ACD/Structure Elucidator）、核磁共振（NMR）光谱的密度泛函理论（DFT）计算以及电子圆二色性（ECD）确定了它们的结构。在生物学方面，使用1,1 - 二苯基 - 2 - 苦基肼（DPPH）测定法评估，化合物 - 表现出潜在的抗氧化活性，IC值范围为27.8至89.6μM。特别是，化合物 和 表现出与阳性对照抗坏血酸相当的自由基清除活性，IC值分别为27.8和31.2μM。此外，化合物 通过抑制脂多糖（LPS）诱导的RAW 264.7巨噬细胞中一氧化氮（NO）的产生表现出潜在的抗炎活性，IC值为52.7μM。这些发现强调了新的山梨素类衍生物在抗氧化和抗炎应用方面的治疗潜力。
