Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China.
Mar Drugs. 2024 Sep 25;22(10):433. doi: 10.3390/md22100433.
Inflammation is considered as one of the most primary protective innate immunity responses, closely related to the body's defense mechanism for responding to chemical, biological infections, or physical injuries. Furthermore, prolonged inflammation is undesirable, playing an important role in the development of various diseases, such as heart disease, diabetes, Alzheimer's disease, atherosclerosis, rheumatoid arthritis, and even certain cancers. Marine-derived fungi represent promising sources of structurally novel bioactive natural products, and have been a focus of research for the development of anti-inflammatory drugs. This review covers secondary metabolites with anti-inflammatory activities from marine-derived fungi, over the period spanning August 2018 to July 2024. A total of 285 anti-inflammatory metabolites, including 156 novel compounds and 11 with novel skeleton structures, are described. Their structures are categorized into five categories: terpenoids, polyketides, nitrogen-containing compounds, steroids, and other classes. The biological targets, as well as the in vitro and in vivo screening models, were surveyed and statistically summarized. This paper aims to offer valuable insights to researchers in the exploration of natural products and the discovery of anti-inflammatory drugs.
炎症被认为是最主要的先天保护免疫反应之一，与身体对化学、生物感染或物理损伤的防御机制密切相关。此外，长期的炎症是不理想的，它在各种疾病的发展中起着重要作用，如心脏病、糖尿病、阿尔茨海默病、动脉粥样硬化、类风湿性关节炎，甚至某些癌症。海洋来源的真菌是具有结构新颖的生物活性天然产物的有前途的来源，一直是开发抗炎药物研究的重点。本综述涵盖了 2018 年 8 月至 2024 年 7 月期间海洋来源真菌中具有抗炎活性的次生代谢产物。共描述了 285 种抗炎代谢产物，包括 156 种新化合物和 11 种具有新型骨架结构的化合物。它们的结构分为五类：萜类、聚酮类、含氮化合物、甾体和其他类。调查并统计总结了生物靶点以及体外和体内筛选模型。本文旨在为研究人员探索天然产物和发现抗炎药物提供有价值的见解。
