海洋来源真菌 7227 中抑制 NO 的 Fusarins G-L

School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, China.

Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai 519082, China.

Mar Drugs. 2021 May 25;19(6):305. doi: 10.3390/md19060305.

Six new fusarin derivatives, fusarins G-L (-), together with five known compounds (-) were isolated from the marine-derived fungus 7227. The structures of the new compounds were elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, HRESIMS, ECD, and ORC) and X-ray crystallography. Compounds - exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide, with IC values ranging from 3.6 to 32.2 μM. The structure-activity relationships of the fusarins are discussed herein.

从海洋来源真菌 7227 中分离得到了六个新的伏马菌素衍生物，即伏马菌素 G-L(-)，以及五个已知化合物(-)。通过综合光谱方法（1D 和 2D NMR、HRESIMS、ECD 和 ORC）和 X 射线晶体学确定了新化合物的结构。化合物-通过抑制脂多糖激活的 RAW264.7 细胞中 NO 的产生表现出强烈的抗炎活性，IC 值范围为 3.6 至 32.2 μM。本文讨论了伏马菌素的结构-活性关系。