Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta Hospital, Girona, Spain; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain; CIBER Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain; Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain.
Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta Hospital, Girona, Spain; CIBER Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain; Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain.
Cell Host Microbe. 2024 Aug 14;32(8):1248-1263. doi: 10.1016/j.chom.2024.07.019.
This perspective explores the current understanding of the gut microbiota's impact on cognitive function in apparently healthy humans and in individuals with metabolic disease. We discuss how alterations in gut microbiota can influence cognitive processes, focusing not only on bacterial composition but also on often overlooked components of the gut microbiota, such as bacteriophages and eukaryotes, as well as microbial functionality. We examine the mechanisms through which gut microbes might communicate with the central nervous system, highlighting the complexity of these interactions. We provide a comprehensive overview of the emerging field of microbiota-gut-brain interactions and its significance for cognitive health. Additionally, we summarize novel therapeutic strategies designed to promote cognitive resilience and reduce the risk of cognitive disorders, focusing on interventions that target the gut microbiota. An in-depth understanding of the microbiome-brain axis is imperative for developing innovative treatments aimed at improving cognitive health.
这篇观点文章探讨了目前人们对肠道微生物群对明显健康人群和代谢性疾病患者认知功能影响的理解。我们讨论了肠道微生物群的改变如何影响认知过程，不仅关注细菌组成，还关注肠道微生物群中经常被忽视的成分，如噬菌体和真核生物，以及微生物功能。我们研究了肠道微生物与中枢神经系统相互作用的机制，强调了这些相互作用的复杂性。我们全面概述了新兴的微生物群-肠道-大脑相互作用领域及其对认知健康的意义。此外，我们总结了旨在促进认知弹性和降低认知障碍风险的新型治疗策略，重点关注针对肠道微生物群的干预措施。深入了解微生物群-大脑轴对于开发旨在改善认知健康的创新治疗方法至关重要。
