Lee Yung-Sung, Kang Eugene Yu-Chuan, Chen Henry Shen-Lih, Yeh Po-Han, Wu Wei-Chi
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Department of Ophthalmology, New Taipei Municipal Tucheng Hospital, New Taipei City, Taiwan.
Eye (Lond). 2024 Jul;38(10):1964-1970. doi: 10.1038/s41433-024-03053-w. Epub 2024 Apr 17.
To evaluate the morphology of lamina cribrosa (LC) in preterm school-aged children.
A study of 120 eyes from 120 patients, including 42 full-term children (control group), 41 preterm children without retinopathy of prematurity (ROP), 16 children with ROP treated with intravitreal bevacizumab (IVB), and 21 children with ROP treated with laser. Five parameters of LC were measured by optical coherence tomography, including Bruch's membrane opening (BMO) diameter, minimum rim width (MRW), LC depth, prelaminar tissue (PLT) thickness, and LC curvature index (LCCI).
The PLT thickness increased with age in full-term and preterm children (β = 30.1, P = 0.003 and β = 19.6, P < 0.001, respectively). LC depth and LCCI showed no differences between full-term and preterm children. Worse refractive errors in preterm children were associated with greater MRW and PLT thickness (β = -17.1, P = 0.001 and β = -5.7, P = 0.03, respectively). However, this relationship was not found in full-term children. Laser-treated children had greater MRW, PLT, temporal peripapillary retinal nerve fibre layer, and foveal thickness than full-term or other preterm children (all P < 0.05).
Prematurity and ROP treatment may have an impact on the structural development of the LC. Refractive status plays a vital role in the LC structure of preterm children. This highlights the refractive errors of preterm children at school age that merit greater attention.
评估学龄期早产儿筛板（LC）的形态。
对120例患者的120只眼进行研究，其中包括42名足月儿（对照组）、41名无早产儿视网膜病变（ROP）的早产儿、16名接受玻璃体内注射贝伐单抗（IVB）治疗的ROP患儿以及21名接受激光治疗的ROP患儿。通过光学相干断层扫描测量LC的五个参数，包括布鲁赫膜开口（BMO）直径、最小边缘宽度（MRW）、LC深度、板层前组织（PLT）厚度和LC曲率指数（LCCI）。
足月儿和早产儿的PLT厚度均随年龄增加（β分别为30.1，P = 0.003和β为19.6，P < 0.001）。足月儿和早产儿的LC深度和LCCI无差异。早产儿较差的屈光不正与更大的MRW和PLT厚度相关（β分别为-17.1，P = 0.001和β为-5.7，P = 0.03）。然而，在足月儿中未发现这种关系。接受激光治疗的患儿的MRW、PLT、颞侧视盘周围视网膜神经纤维层和黄斑厚度均大于足月儿或其他早产儿（所有P < 0.05）。
早产和ROP治疗可能对LC的结构发育有影响。屈光状态在早产儿的LC结构中起重要作用。这突出了学龄期早产儿的屈光不正问题值得更多关注。
