Department of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou, China.
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou, China.
BMC Public Health. 2024 Apr 17;24(1):1069. doi: 10.1186/s12889-024-18515-9.
Sedentary behavior has been demonstrated to be a modifiable factor for several chronic diseases, while coffee consumption is believed to be beneficial for health. However, the joint associations of daily sitting time and coffee consumption with mortality remains poorly understood. This study aimed to evaluate the independent and joint associations of daily sitting time and coffee intakes with mortality from all-cause and cardiovascular disease (CVD) among US adults.
An analysis of a prospective cohort from the 2007-2018 National Health and Nutrition Examination Survey of US adults (n = 10,639). Data on mortality were compiled from interview and physical examination data until December 31, 2019. Daily sitting time was self-reported. Coffee beverages were from the 24-hour diet recall interview. The main outcomes of the study were all-cause and cardiovascular disease mortality. The adjusted hazard ratios [HRs] and 95% confidence intervals [CI] were imputed by Cox proportional hazards regression.
Among 10,639 participants in the study cohort, there were 945 deaths, 284 of whom died of CVD during the follow-up period of up to 13 years. Multivariable models showed that sitting more than 8 h/d was associated with higher risks of all-cause (HR, 1.46; 95% CI, 1.17-1.81) and CVD (HR, 1.79; 95% CI, 1.21-2.66) mortality, compared with those sitting for less than 4 h/d. People with the highest quartile of coffee consumption were observed for the reduced risks of both all-cause (HR, 0.67; 95% CI, 0.54-0.84) and CVD (HR, 0.46; 95% CI, 0.30-0.69) mortality compared with non-coffee consumers. Notably, joint analyses firstly showed that non-coffee drinkers who sat six hours or more per day were 1.58 (95% CI, 1.25-1.99) times more likely to die of all causes than coffee drinkers sitting for less than six hours per day, indicating that the association of sedentary with increased mortality was only observed among adults with no coffee consumption but not among those who had coffee intake.
This study identified that sedentary behavior for more than 6 h/d accompanied with non-coffee consumption, were strongly associated with the increased risk of mortality from all-cause and CVD.
久坐行为已被证明是多种慢性疾病的可改变因素，而咖啡的摄入被认为对健康有益。然而，每日久坐时间和咖啡摄入量与死亡率之间的联合关联仍知之甚少。本研究旨在评估美国成年人中，每日久坐时间和咖啡摄入量与全因和心血管疾病（CVD）死亡率的独立和联合关联。
对美国成年人 2007-2018 年国家健康和营养检查调查的前瞻性队列进行分析（n=10639）。死亡率数据来自于截至 2019 年 12 月 31 日的访谈和体检数据。每日久坐时间由自我报告得出。咖啡饮品来自 24 小时饮食回顾访谈。本研究的主要结局为全因和心血管疾病死亡率。通过 Cox 比例风险回归推断调整后的危险比（HR）和 95%置信区间（CI）。
在研究队列的 10639 名参与者中，有 945 人死亡，其中 284 人在随访期间死于 CVD，时间长达 13 年。多变量模型显示，每天坐 8 小时以上与全因死亡风险增加相关（HR，1.46；95%CI，1.17-1.81）和 CVD（HR，1.79；95%CI，1.21-2.66），与每天坐不到 4 小时相比。与非咖啡饮用者相比，咖啡摄入量最高四分位数的人观察到全因（HR，0.67；95%CI，0.54-0.84）和 CVD（HR，0.46；95%CI，0.30-0.69）死亡率降低。值得注意的是，联合分析首次表明，每天坐 6 小时或以上且不喝咖啡的人死于全因的风险比每天坐不到 6 小时且喝咖啡的人高 1.58 倍（95%CI，1.25-1.99），这表明久坐与死亡率增加的关联仅见于不喝咖啡摄入的成年人中，而不是喝咖啡摄入的成年人中。
本研究发现，每天坐 6 小时以上且不喝咖啡的行为与全因和 CVD 死亡率增加的风险密切相关。
