Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, 100029, Beijing, P.R. China.
J Cardiothorac Surg. 2024 Apr 18;19(1):244. doi: 10.1186/s13019-024-02717-8.
conventional coronary artery bypass grafting (CCABG) tends to cause severe complications in patients with comorbid Coronary Artery Diseases (CAD) and diabetes. On the other hand, the Minimally Invasive Cardiac Surgery Coronary Artery Bypass Grafting (MICS CABG) via transthoracic incision is associated with rapid recovery and reduced complications. Adding to the limited literature, this study compares CCABG and MICS CABG in terms of efficacy and safety.
Herein, 104 CCABG and MICS CABG cases (52 cases each) were included. The patients were recruited from the Minimally Invasive Cardiac Surgery Center, Anzhen Hospital, between January 2017 and December 2021 and were selected based on the Propensity Score Matching (PSM) model. The key outcomes included All-cause Death, Myocardial Infarction (MI), Cerebrovascular Events, revascularization, Adverse Wound Healing Events and one-year patency of the graft by coronary CTA.
Compared to CCABG, MICS CABG had longer surgical durations [4.25 (1.50) h vs.4.00 (1.13) h, P = 0.028], but showed a reduced intraoperative blood loss [600.00 (400.00) mL vs.700.00 (300.00) mL, P = 0.032] and a lower secondary incision debridement and suturing rate (5.8% vs.19.2%, P = 0.038). In follow up, no statistically significant differences were found between the two groups in the cumulative Major Adverse Cardiovascular and Cerebrovascular Events (MACCEs) incidence (7.7% vs. 5.9%), all-cause mortality (0 vs. 0), MI incidence (1.9% vs. 2.0%), cerebral apoplexy incidence (5.8% vs. 3.9%), and repeated revascularization incidence (0 vs. 0) (P > 0.05). Additionally, coronary CTA results revealed that the two groups' one-year graft patency (94.2% vs. 90.2%, P = 0.761) showed no statistically significant difference.
In patients with comorbid CAD and diabetes, MICS CABG and CCABG had comparable revascularization performances. Moreover, MICS CABG can effectively reduce, if not prevent, poor clinical outcomes/complications, including incision healing, sternal infection and prolonged length of stay in diabetes patients.
传统的冠状动脉旁路移植术(CCABG)在合并冠心病和糖尿病的患者中往往会引起严重的并发症。另一方面,经胸小切口微创心脏外科冠状动脉旁路移植术(MICS CABG)具有快速康复和减少并发症的特点。此外,这项研究比较了 CCABG 和 MICS CABG 在疗效和安全性方面的差异。
在此,纳入了 104 例 CCABG 和 MICS CABG 病例(各 52 例)。这些患者是 2017 年 1 月至 2021 年 12 月期间在北京安贞医院微创心脏外科中心招募的,根据倾向评分匹配(PSM)模型进行选择。主要结局包括全因死亡、心肌梗死(MI)、脑血管事件、血运重建、不良伤口愈合事件以及通过冠状动脉 CTA 评估的移植物一年通畅率。
与 CCABG 相比,MICS CABG 的手术时间更长[4.25(1.50)h 比 4.00(1.13)h,P=0.028],但术中出血量更少[600.00(400.00)mL 比 700.00(300.00)mL,P=0.032],二次切口清创缝合率也更低(5.8%比 19.2%,P=0.038)。在随访中,两组间累积主要不良心脑血管事件(MACCEs)发生率(7.7%比 5.9%)、全因死亡率(0 比 0)、MI 发生率(1.9%比 2.0%)、脑卒发生率(5.8%比 3.9%)和重复血运重建发生率(0 比 0)均无统计学差异(P>0.05)。此外,冠状动脉 CTA 结果显示两组的一年移植物通畅率(94.2%比 90.2%,P=0.761)也无统计学差异。
在合并 CAD 和糖尿病的患者中,MICS CABG 和 CCABG 的血运重建效果相当。此外,MICS CABG 可以有效减少(如果不能预防的话)糖尿病患者的不良临床结局/并发症,包括切口愈合不良、胸骨感染和住院时间延长。