Li Jiawen, Warren-Smith Stephen C, McLaughlin Robert A, Ebendorff-Heidepriem Heike
School of Electrical and Mechanical Engineering, The University of Adelaide, South Australia, 5005, Australia.
Institute for Photonics and Advanced Sensing, The University of Adelaide, South Australia, 5005, Australia.
Biomed Opt Express. 2024 Mar 15;15(4):2392-2405. doi: 10.1364/BOE.517920. eCollection 2024 Apr 1.
Single-fiber-based sensing and imaging probes enable the co-located and simultaneous observation and measurement (i.e., 'sense' and 'see') of intricate biological processes within deep anatomical structures. This innovation opens new opportunities for investigating complex physiological phenomena and potentially allows more accurate diagnosis and monitoring of disease. This prospective review starts with presenting recent studies of single-fiber-based probes for concurrent and co-located fluorescence-based sensing and imaging. Notwithstanding the successful initial demonstration of integrated sensing and imaging within single-fiber-based miniaturized devices, the realization of these devices with enhanced sensing sensitivity and imaging resolution poses notable challenges. These challenges, in turn, present opportunities for future research, including the design and fabrication of complex lens systems and fiber architectures, the integration of novel materials and other sensing and imaging techniques.
基于单纤维的传感与成像探针能够对深部解剖结构内复杂的生物过程进行共定位和同步观察与测量（即“感知”和“观察”）。这一创新为研究复杂的生理现象带来了新机遇，并有可能实现更准确的疾病诊断和监测。这篇前瞻性综述首先介绍了基于单纤维的探针用于并发和共定位荧光传感与成像的近期研究。尽管在基于单纤维的小型化设备中成功进行了集成传感和成像的初步演示，但要实现具有更高传感灵敏度和成像分辨率的这些设备仍面临显著挑战。反过来，这些挑战也为未来的研究提供了机遇，包括复杂透镜系统和光纤架构的设计与制造、新型材料的集成以及其他传感和成像技术。
