Nam Nguyen Nhat, Tran Nguyen Khoi Song, Nguyen Tan Tai, Trai Nguyen Ngoc, Thuy Nguyen Phuong, Do Hoang Dang Khoa, Tran Nhu Hoa Thi, Trinh Kieu The Loan
Applied Biology Center, School of Agriculture and Aquaculture, Tra Vinh University, Tra Vinh City 87000, Vietnam.
College of Korean Medicine, Gachon University, 1342 Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Beilstein J Nanotechnol. 2024 Apr 12;15:396-415. doi: 10.3762/bjnano.15.36. eCollection 2024.
Antioxidants play an important role in the prevention of oxidative stress and have been widely used in medicine and healthcare. However, natural antioxidants have several limitations such as low stability, difficult long-term storage, and high cost of large-scale production. Along with significant advances in nanotechnology, nanomaterials have emerged as a promising solution to improve the limitations of natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Among various types of nanomaterials exhibiting antioxidant activity, metal-based nanoantioxidants show excellent reactivity because of the presence of an unpaired electron in their atomic structure. In this review, we summarize some novel metal-based nanoantioxidants and classify them into two main categories, namely chain-breaking and preventive antioxidant nanomaterials. In addition, the applications of antioxidant nanomaterials in medicine and healthcare are also discussed. This review provides a deeper understanding of the mechanisms of metal-based nanoantioxidants and a guideline for using these nanomaterials in medicine and healthcare.
抗氧化剂在预防氧化应激中发挥着重要作用，并且已在医学和医疗保健领域广泛应用。然而，天然抗氧化剂存在一些局限性，如稳定性低、难以长期储存以及大规模生产成本高。随着纳米技术的重大进展，纳米材料因其高稳定性、易于储存、时效性和低成本，已成为改善天然抗氧化剂局限性的一种有前景的解决方案。在各种表现出抗氧化活性的纳米材料中，金属基纳米抗氧化剂由于其原子结构中存在未成对电子而具有出色的反应性。在本综述中，我们总结了一些新型金属基纳米抗氧化剂，并将它们分为两大类，即链断裂型和预防型抗氧化纳米材料。此外，还讨论了抗氧化纳米材料在医学和医疗保健中的应用。本综述有助于更深入地理解金属基纳米抗氧化剂的作用机制，并为在医学和医疗保健中使用这些纳米材料提供指导。
