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海枣乙醇提取物的生物活性定量分析

Quantification of the Bioactivity of Ethanolic Extract From Phoenix dactylifera.

作者信息

Soni Jeesha, Panneer Selvam Suganya, Shanmugam Rajeshkumar, Ramadoss Ramya, Sundar Sandhya

机构信息

Department of Oral Biology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.

Nanobiomedicine Lab, Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.

出版信息

Cureus. 2024 Mar 18;16(3):e56391. doi: 10.7759/cureus.56391. eCollection 2024 Mar.

DOI:10.7759/cureus.56391
PMID:38633945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11023018/
Abstract

AIM

This study aims to quantitatively assess the anti-inflammatory and antioxidant activities of the ethanolic extract of seeds.

MATERIALS AND METHODS

Around 30 seeds of were collected, crushed, and powdered; 10 gm of powder was added to 100 ml of ethanolic extract and boiled for further analysis. Egg albumin denaturation assay and hydroxyl radical scavenging assay were done to evaluate the anti-inflammatory and antioxidant activity, respectively. An independent t-test was used to compare the anti-inflammatory and antioxidant potential of the ethanolic extract of using SPSS Statistics version 22.0 (IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0; Armonk, NY: IBM Corp.), and values less than 0.05 are considered statistically significant.

RESULTS

The seeds of have potent anti-inflammatory and antioxidant properties. Both anti-inflammatory and antioxidant properties improved with higher concentrations and were comparable to the control substances diclofenac sodium, vitamin E, and ascorbic acid, respectively. The most significant anti-inflammatory and antioxidant effect was observed at a dosage of 50 μL, with a p-value of 0.001.

CONCLUSION

To conclude, we found that the ethanolic extract of has anti-inflammatory and antioxidant activity, which can further be used for the improvement of pharmaceuticals.

摘要

目的

本研究旨在定量评估[种子名称未给出]种子乙醇提取物的抗炎和抗氧化活性。

材料与方法

收集约30颗[种子名称未给出]种子，碾碎并磨成粉末；将10克粉末加入100毫升乙醇提取物中并煮沸以进行进一步分析。分别进行蛋清蛋白变性试验和羟自由基清除试验以评估抗炎和抗氧化活性。使用SPSS Statistics 22.0版本（IBM公司。2013年发布。适用于Windows的IBM SPSS Statistics，版本22.0；纽约州阿蒙克：IBM公司）进行独立t检验，以比较[种子名称未给出]乙醇提取物的抗炎和抗氧化潜力，p值小于0.05被认为具有统计学意义。

结果

[种子名称未给出]种子具有强大的抗炎和抗氧化特性。抗炎和抗氧化特性均随浓度升高而增强，且分别与对照物质双氯芬酸钠、维生素E和抗坏血酸相当。在50微升剂量下观察到最显著的抗炎和抗氧化作用，p值为0.001。

结论

总之，我们发现[种子名称未给出]乙醇提取物具有抗炎和抗氧化活性，可进一步用于改进药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d57/11023018/b5b339e0c451/cureus-0016-00000056391-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d57/11023018/1810d2b77840/cureus-0016-00000056391-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d57/11023018/b5b339e0c451/cureus-0016-00000056391-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d57/11023018/1810d2b77840/cureus-0016-00000056391-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d57/11023018/b5b339e0c451/cureus-0016-00000056391-i02.jpg

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