Nagesh Shweta, Kumaran Kirthick, Mani Pugazh
Orthodontics and Dentofacial Orthopedics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Dentistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus. 2024 Mar 18;16(3):e56388. doi: 10.7759/cureus.56388. eCollection 2024 Mar.
Aim The study aims to characterize Fe and Mg co-substituted hydroxyapatite nanoparticles (FeMgHAPn) and assess the antimicrobial properties of FeMgHAPn-incorporated orthodontic composite. Materials and methods FeMgHAPn was synthesized using the sol-gel method, and the prepared nanoparticle powder was characterized using Fourier Transform Infrared Spectroscopy (FTIR), energy-dispersive X-ray analysis (EDX)) and scanning electron microscopic (SEM) analysis. The FeMgHAPn was incorporated into a commercially available orthodontic composite in two concentrations (40 and 20 μL), and the structure was examined using SEM. The FeMgHAPn-incorporated composite was tested for its antimicrobial efficacy against , , and using the agar-well diffusion method. The zones of inhibition (ZOI) were measured in millimeters (mm). Results The characterization of the FeMgHAPn indicated the successful formation of the nanoparticle without any impurities or byproducts. The high concentration (40 μL) of FeMgHAPn-incorporated orthodontic composite showed the maximum ZOI against all three microbes, followed by the low concentration (20 μL) and the control group. Conclusion The FeMgHAPn-incorporated orthodontic composite showed promising antimicrobial activity against caries-causing , , and .
目的 本研究旨在对铁和镁共取代羟基磷灰石纳米颗粒（FeMgHAPn）进行表征，并评估掺入FeMgHAPn的正畸复合材料的抗菌性能。材料与方法 采用溶胶-凝胶法合成FeMgHAPn，并使用傅里叶变换红外光谱（FTIR）、能量色散X射线分析（EDX）和扫描电子显微镜（SEM）分析对制备的纳米颗粒粉末进行表征。将FeMgHAPn以两种浓度（40和20 μL）掺入市售正畸复合材料中，并使用SEM检查其结构。采用琼脂孔扩散法测试掺入FeMgHAPn的复合材料对变形链球菌、白色念珠菌和远缘链球菌的抗菌效果。测量抑菌圈（ZOI）的大小，单位为毫米（mm）。结果 FeMgHAPn的表征表明成功形成了无任何杂质或副产物的纳米颗粒。高浓度（40 μL）掺入FeMgHAPn的正畸复合材料对所有三种微生物均表现出最大的抑菌圈，其次是低浓度（20 μL）组和对照组。结论 掺入FeMgHAPn的正畸复合材料对致龋的变形链球菌、白色念珠菌和远缘链球菌显示出有前景的抗菌活性。
