Cuenca Alcocel José, Villalba-Heredia Lorena, Martínez Redondo Inés, Berrozpe-Villabona Clara, Casajús José Antonio, Arbonés-Mainar José Miguel, Calmarza Pilar
Service of Clinical Biochemistry, Obispo Polanco Hospital, Teruel, Spain.
GENUD Research Group, University of Zaragoza, Zaragoza, Spain.
Adv Lab Med. 2024 Mar 8;5(1):66-74. doi: 10.1515/almed-2024-0026. eCollection 2024 Mar.
Bone mass progressively increases to peak during childhood and adolescence, which determines future bone health. Bone formation-resorption processes are assessed using bone markers. However, studies on the impact of obesity on bone turnover markers at this age are limited, and results are inconsistent. The objective of this study was to examine the potential impact of overweight/obesity on bone metabolism.
A study was performed to compare parameters of bone metabolism in 45 girls and boys with normal weight (controls) and in a group of 612 girls and boys with overweight/obesity (cases) from the Exergames study (University of Zaragoza). Ages ranged from 8 to 12 years.
Higher values of phosphorus and IGFBP-3 were observed in children with overweight/obesity, as compared to children with normal weight, (p=0.042) and (p=0.042), respectively. BAP, osteocalcin, magnesium, vitamin D and IGF-I concentrations were lower in the group with overweight/obesity, whereas calcium concentrations were higher in this group, although differences were not statistically significant. A negative correlation was found (r=-0.193) (p=0.049) between BAP and BMI.
Although differences did not reach statistical significance, BAP and osteocalcin concentrations were lower in children with overweight/obesity. This added to the negative correlation found between BAP and MIC may demonstrate that overweight/obesity may negatively affect bone health already at a young age.
在儿童和青少年时期，骨量会逐渐增加至峰值，这决定了未来的骨骼健康。骨形成-吸收过程可通过骨标志物进行评估。然而，关于肥胖对该年龄段骨转换标志物影响的研究有限，且结果不一致。本研究的目的是探讨超重/肥胖对骨代谢的潜在影响。
进行了一项研究，比较了来自萨拉戈萨大学“运动游戏”研究中45名体重正常的女孩和男孩（对照组）与612名超重/肥胖的女孩和男孩（病例组）的骨代谢参数。年龄范围为8至12岁。
与体重正常的儿童相比，超重/肥胖儿童的磷和IGFBP - 3值更高，分别为（p = 0.042）和（p = 0.042）。超重/肥胖组的骨碱性磷酸酶（BAP）、骨钙素、镁、维生素D和IGF - I浓度较低，而该组的钙浓度较高，尽管差异无统计学意义。BAP与体重指数（BMI）之间存在负相关（r = -0.193）（p = 0.049）。
尽管差异未达到统计学意义，但超重/肥胖儿童的BAP和骨钙素浓度较低。这与BAP和BMI之间的负相关共同表明，超重/肥胖可能在年轻时就对骨骼健康产生负面影响。
