全球、地区和国家因空腹血糖升高导致的失明和视力丧失负担，以及 1990 年至 2019 年的预测数据，到 2030 年：2019 年全球疾病负担研究的系统分析。

Global, regional, and national burden of blindness and vision loss attributable to high fasting plasma glucose from 1990 to 2019, and forecasts to 2030: A systematic analysis for the Global Burden of Disease Study 2019.

机构信息

Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

School of Medicine South China University of Technology, Guangzhou, China.

出版信息

Diabetes Metab Res Rev. 2024 May;40(4):e3802. doi: 10.1002/dmrr.3802.

DOI:10.1002/dmrr.3802

PMID:38634501

Abstract

AIMS

To systematically clarify the spatiotemporal trends, and age-sex-specific blindness and vision loss (BVL) burden due to high fasting plasma glucose (HFPG) from 1990 to 2019, and project this burden over the next decade.

MATERIALS AND METHODS

We obtained the number and rate of years lived with disability (YLDs) for the BVL burden attributable to HFPG by age, sex, socio-demographic index (SDI), and location between 1990 and 2019 from the Global Burden of Disease (GBD) 2019 database. The average annual percentage changes (AAPCs) were calculated to assess the temporal trends of HFPG-attributable BVL burden. The Bayesian age-period-cohort model was used to predict the HFPG-attributable BVL burden.

RESULTS

In 2019, the global number and age-standardized rate (ASR) for YLDs of BVL attributable to HFPG were 673.13 (95% UI: 159.52 to 1565.34) thousand and 8.44 (95% UI: 2.00 to 19.63) per 100,000 people, respectively. The highest burdens were found in Oceania, South Asia, and Southeast Asia, and the BVL burden due to HFPG was higher in the elderly and lower SDI regions. From 1990 to 2019, the global ASR of HFPG-attributable BVL gradually increased with AAPC (95% CI) being 0.80 (0.74 to 0.86). In addition, the HFPG-attributable BVL burden will slightly increase in the future decade.

CONCLUSIONS

The HFPG remains the important cause of BVL worldwide, placing a substantial disease burden. From 1990 to 2019, the age-standardized burden of BVL due to HFPG increased, and will consistently increase in the future decade, particularly in the elderly and in regions with middle SDI or below.

摘要

目的

系统阐明 1990 年至 2019 年高空腹血糖（HFPG）导致的时空趋势以及盲和视力损伤（BVL）负担的年龄性别特异性，并预测未来十年的这一负担。

材料和方法

我们从 2019 年全球疾病负担（GBD）数据库中获得了 1990 年至 2019 年期间因 HFPG 导致的 BVL 负担的残疾年数（YLD）数量和发生率，以及按年龄、性别、社会人口指数（SDI）和地点划分的 YLD 数量和发生率。计算了平均年百分比变化（AAPC）以评估 HFPG 导致的 BVL 负担的时间趋势。使用贝叶斯年龄-时期-队列模型预测 HFPG 导致的 BVL 负担。

结果

2019 年，全球因 HFPG 导致的 BVL 的 YLD 数量和年龄标准化率（ASR）分别为 673.13（95%置信区间：159.52 至 1565.34）千和 8.44（95%置信区间：2.00 至 19.63）每 100,000 人。负担最重的地区是大洋洲、南亚和东南亚，而 HFPG 导致的 BVL 负担在老年人和 SDI 较低的地区较高。从 1990 年到 2019 年，全球 HFPG 导致的 BVL 的 ASR 逐渐增加，AAPC（95%置信区间）为 0.80（0.74 至 0.86）。此外，未来十年 HFPG 导致的 BVL 负担将略有增加。