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Is Ia antigen expression by thymic epithelial cells constitutive?

作者信息

Rouse R V

出版信息

Adv Exp Med Biol. 1985;186:915-9. doi: 10.1007/978-1-4613-2463-8_110.

DOI:10.1007/978-1-4613-2463-8_110
PMID:3863476
Abstract

Thymic epithelial cells express class II MHC antigens (Ia) in the normal thymus. In a variety of special circumstances, generally associated with decreased or absent thymocyte populations, TEC fail to express Ia antigens. Although such observations might be interpreted based on the hypothesis that TEC Ia antigens have an effect on the differentiation of thymocytes, it is also possible that instead, the thymocytes have an effect on TEC Ia antigen expression.

摘要

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