Danaeifar Mohsen, Najafi Ali
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Science, P.O. Box 19395-5487, Tehran, Iran.
Biochem Genet. 2025 Apr;63(2):960-983. doi: 10.1007/s10528-024-10799-1. Epub 2024 Apr 18.
One of the trending fields in almost all areas of science and technology is artificial intelligence. Computational biology and artificial intelligence can help gene therapy in many steps including: gene identification, gene editing, vector design, development of new macromolecules and modeling of gene delivery. There are various tools used by computational biology and artificial intelligence in this field, such as genomics, transcriptomic and proteomics data analysis, machine learning algorithms and molecular interaction studies. These tools can introduce new gene targets, novel vectors, optimized experiment conditions, predict the outcomes and suggest the best solutions to avoid undesired immune responses following gene therapy treatment.
几乎在所有科学技术领域中,人工智能都是热门领域之一。计算生物学和人工智能可以在基因治疗的许多步骤中发挥帮助作用,包括:基因识别、基因编辑、载体设计、新大分子的开发以及基因传递建模。在这一领域,计算生物学和人工智能使用了各种工具,例如基因组学、转录组学和蛋白质组学数据分析、机器学习算法以及分子相互作用研究。这些工具可以引入新的基因靶点、新型载体、优化实验条件、预测结果,并提出最佳解决方案,以避免基因治疗后出现不良免疫反应。