Department of Food Science and Technology, Pukyong National University, Busan 48513, Republic of Korea; Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea.
Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea; Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Republic of Korea; Institute of Fisheries Science, Pukyong National University, Busan 48513, Republic of Korea.
Trends Biotechnol. 2024 Oct;42(10):1288-1304. doi: 10.1016/j.tibtech.2024.03.009. Epub 2024 Apr 18.
Microbial infections are major human health issues, and, recently, the mortality rate owing to bacterial and fungal infections has been increasing. In addition to intrinsic and extrinsic antimicrobial resistance mechanisms, biofilm formation is a key adaptive resistance mechanism. Several bioactive compounds from marine organisms have been identified for use in biofilm therapy owing to their structural complexity, biocompatibility, and economic viability. In this review, we discuss recent trends in the application of marine natural compounds, marine-bioinspired nanomaterials, and marine polymer conjugates as possible therapeutic agents for controlling biofilms and virulence factors. We also comprehensively discuss the mechanisms underlying biofilm formation and inhibition of virulence factors by marine-derived materials and propose possible applications of novel and effective antibiofilm and antivirulence agents.
微生物感染是人类健康的主要问题，最近，由于细菌和真菌感染导致的死亡率一直在上升。除了内在和外在的抗菌耐药机制外，生物膜的形成是一种关键的适应性耐药机制。由于结构复杂性、生物相容性和经济可行性，已经从海洋生物中鉴定出几种具有生物膜治疗用途的生物活性化合物。在这篇综述中，我们讨论了海洋天然化合物、海洋仿生纳米材料和海洋聚合物缀合物作为控制生物膜和毒力因子的潜在治疗剂的最新应用趋势。我们还全面讨论了海洋衍生材料抑制生物膜形成和抑制毒力因子的机制，并提出了新型有效抗生物膜和抗毒力剂的可能应用。
