van de Wetering B J, Martens C M, Fortgens C, Slaets J P, van Woerkom T C
Clin Neurol Neurosurg. 1985;87(3):181-6. doi: 10.1016/0303-8467(85)90004-6.
Late components (N1, P2, N2, P3) of the event-related potential (ERP) elicited by simple auditory discrimination tasks were investigated in 6 patients with Gilles de la Tourette syndrome. The ERP's were registrated in the patients before and during drug treatment as well as in 16 healthy controls. It appeared that in Tourette syndrome the N2 and P2 waveforms (target response) at Cz and Pz were remarkably less well identifiable. The results did not reveal P3 abnormalities in the patients. However, the patients demonstrated definite changes in the N1 and P2 components as compared to the controls. The N1 amplitudes were decreased in the patients. During drug treatment the N1 amplitudes increased although they remained smaller than in the controls. It is concluded that Tourette patients have no abnormalities in early and late components, but that specifically the components between 90-280 ms are affected. These abnormalities may reflect specific attention deficits which often occur in Tourette syndrome.
对6例患有抽动秽语综合征的患者进行了研究，调查了简单听觉辨别任务诱发的事件相关电位（ERP）的晚期成分（N1、P2、N2、P3）。在药物治疗前、治疗期间对患者以及16名健康对照者进行了ERP记录。结果显示，在抽动秽语综合征患者中，Cz和Pz处的N2和P2波形（目标反应）明显难以识别。结果未显示患者存在P3异常。然而，与对照组相比，患者的N1和P2成分有明显变化。患者的N1波幅降低。在药物治疗期间，N1波幅增加，尽管仍低于对照组。结论是，抽动秽语综合征患者的早期和晚期成分无异常，但90-280毫秒之间的成分受到了特异性影响。这些异常可能反映了抽动秽语综合征中经常出现的特定注意力缺陷。
