Smith S J, Lees A J
Department of Clinical Neurophysiology, National Hospital for Nervous Diseases, London, UK.
J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):895-8. doi: 10.1136/jnnp.52.7.895.
The blink reflex and it's recovery cycle were studied in 26 patients with Gilles de la Tourette syndrome and 10 controls. There was a significant increase in the mean duration of the R2 response. The amplitude of the R2 response following paired shocks (mean R2[T]/R2[C]%) was 11%, 40% and 52% of the conditioning stimulus with intervals of 200 ms, 500 ms and 1 second in the patients, compared with 10%, 17% and 32% respectively in the controls. Half the patients, however, had normal recovery cycles and voluntary suppression of tics and blinks reduced the amplitude of R2 in all patients. These results suggest increased excitability of brainstem interneurons in Gilles de la Tourette syndrome.
对26例抽动秽语综合征患者和10名对照者进行了瞬目反射及其恢复周期的研究。R2反应的平均持续时间显著增加。在患者中，配对刺激后R2反应的幅度（平均R2[T]/R2[C]%）在间隔200毫秒、500毫秒和1秒时分别为条件刺激的11%、40%和52%，而在对照者中分别为10%、17%和32%。然而，一半的患者恢复周期正常，并且抽动和瞬目的自主抑制降低了所有患者R2的幅度。这些结果提示抽动秽语综合征患者脑干中间神经元兴奋性增加。
