抽动秽语综合征中瞬目反射的异常。
Abnormalities of the blink reflex in Gilles de la Tourette syndrome.
作者信息
Smith S J, Lees A J
机构信息
Department of Clinical Neurophysiology, National Hospital for Nervous Diseases, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Jul;52(7):895-8. doi: 10.1136/jnnp.52.7.895.
Abstract
The blink reflex and it's recovery cycle were studied in 26 patients with Gilles de la Tourette syndrome and 10 controls. There was a significant increase in the mean duration of the R2 response. The amplitude of the R2 response following paired shocks (mean R2[T]/R2[C]%) was 11%, 40% and 52% of the conditioning stimulus with intervals of 200 ms, 500 ms and 1 second in the patients, compared with 10%, 17% and 32% respectively in the controls. Half the patients, however, had normal recovery cycles and voluntary suppression of tics and blinks reduced the amplitude of R2 in all patients. These results suggest increased excitability of brainstem interneurons in Gilles de la Tourette syndrome.
摘要
对26例抽动秽语综合征患者和10名对照者进行了瞬目反射及其恢复周期的研究。R2反应的平均持续时间显著增加。在患者中，配对刺激后R2反应的幅度（平均R2[T]/R2[C]%）在间隔200毫秒、500毫秒和1秒时分别为条件刺激的11%、40%和52%，而在对照者中分别为10%、17%和32%。然而，一半的患者恢复周期正常，并且抽动和瞬目的自主抑制降低了所有患者R2的幅度。这些结果提示抽动秽语综合征患者脑干中间神经元兴奋性增加。
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本文引用的文献
1
Simple tics in Gilles de la Tourette's syndrome are not prefaced by a normal premovement EEG potential.抽动秽语综合征中的简单抽动在正常的运动前脑电图电位之前不会出现。
J Neurol Neurosurg Psychiatry. 1981 Aug;44(8):735-8. doi: 10.1136/jnnp.44.8.735.
2
Sleep in Gilles de la Tourette's syndrome: disorder of arousal.抽动秽语综合征中的睡眠：觉醒障碍
Neurology. 1983 May;33(5):586-92. doi: 10.1212/wnl.33.5.586.
3
The orbicularis oculi response after hemispheral damage.半球损伤后的眼轮匝肌反应。
J Neurol Neurosurg Psychiatry. 1983 Sep;46(9):837-43. doi: 10.1136/jnnp.46.9.837.
4
Orbicularis oculi reflex in the Wallenberg syndrome: alteration of the late reflex by lesions of the spinal tract and nucleus of the trigeminal nerve.延髓背外侧综合征中的眼轮匝肌反射：三叉神经脊髓束及核病变对晚期反射的影响
J Neurol Neurosurg Psychiatry. 1972 Apr;35(2):228-33. doi: 10.1136/jnnp.35.2.228.
5
Disorder of interneurons in Parkinsonism. The orbicularis oculi reflex to paired stimuli.帕金森病中间神经元的紊乱。眼轮匝肌对成对刺激的反射。
Brain. 1973;96(1):87-96. doi: 10.1093/brain/96.1.87.
6
Human orbicularis oculi reflexes.人类眼轮匝肌反射。
Neurology. 1972 Feb;22(2):149-54. doi: 10.1212/wnl.22.2.149.
7
Pathophysiology of blepharospasm and oromandibular dystonia.眼睑痉挛和口下颌肌张力障碍的病理生理学
Brain. 1985 Sep;108 ( Pt 3):593-608. doi: 10.1093/brain/108.3.593.
8
Blink reflex in patients with hemispheric cerebrovascular accident (CVA). Blink reflex in CVA.半球型脑血管意外（CVA）患者的瞬目反射。CVA患者的瞬目反射。
J Neurol Sci. 1985 Jan;67(1):15-28. doi: 10.1016/0022-510x(85)90018-8.
9
Late components of the auditory evoked potentials in Gilles de la Tourette syndrome.抽动秽语综合征中听觉诱发电位的晚期成分
Clin Neurol Neurosurg. 1985;87(3):181-6. doi: 10.1016/0303-8467(85)90004-6.
10
Blink reflex studies in patients with focal dystonias.局限性肌张力障碍患者的瞬目反射研究
Adv Neurol. 1988;50:517-24.
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