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J Appl Stat. 2019 Jul 9;47(3):393-423. doi: 10.1080/02664763.2019.1639642. eCollection 2020.
3
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A Semi-parametric Transformation Frailty Model for Semi-competing Risks Survival Data.一种用于半竞争风险生存数据的半参数变换脆弱模型。
Scand Stat Theory Appl. 2017 Mar;44(1):112-129. doi: 10.1111/sjos.12244. Epub 2016 Aug 31.
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Survival analysis of breast cancer patients using Cox and frailty models.使用Cox模型和脆弱模型对乳腺癌患者进行生存分析。
J Res Health Sci. 2012 Dec 13;12(2):127-30.
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Repeated events survival models: the conditional frailty model.重复事件生存模型:条件脆弱模型。
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Generalized gamma frailty model.广义伽马脆弱模型
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The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power.使用脆弱性风险模型来处理与治疗相互作用的未识别的异质性:效率和效能的考量。
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9
Analyzing incidence of testis cancer by means of a frailty model.通过脆弱模型分析睾丸癌的发病率。
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10
A comparison of frailty models for multivariate survival data.多变量生存数据的脆弱性模型比较
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具有生存分析的拟伽马脆弱性模型在异质性问题下的验证测试和急诊数据的风险分析。

The quasi-xgamma frailty model with survival analysis under heterogeneity problem, validation testing, and risk analysis for emergency care data.

机构信息

Laboratory of Probabilities and Statistics LaPS, Department of Mathematics, Faculty of Sciences, Badji Mokhtar Annaba University, Annaba, Algeria.

Department of Mathematical Sciences, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.

出版信息

Sci Rep. 2024 Apr 18;14(1):8973. doi: 10.1038/s41598-024-59137-w.

DOI:10.1038/s41598-024-59137-w
PMID:38637600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11026502/
Abstract

Frailty models are important for survival data because they allow for the possibility of unobserved heterogeneity problem. The problem of heterogeneity can be existed due to a variety of factors, such as genetic predisposition, environmental factors, or lifestyle choices. Frailty models can help to identify these factors and to better understand their impact on survival. In this study, we suggest a novel quasi xgamma frailty (QXg-F) model for the survival analysis. In this work, the test of Rao-Robson and Nikulin is employed to test the validity and suitability of the probabilistic model, we examine the distribution's properties and evaluate its performance in comparison with many relevant cox-frailty models. To show how well the QXg-F model captures heterogeneity and enhances model fit, we use simulation studies and real data applications, including a fresh dataset gathered from an emergency hospital in Algeria. According to our research, the QXg-F model is a viable replacement for the current frailty modeling distributions and has the potential to improve the precision of survival analyses in a number of different sectors, including emergency care. Moreover, testing the ability and the importance of the new QXg-F model in insurance is investigated using simulations via different methods and application to insurance data.

摘要

脆弱性模型对于生存数据分析非常重要,因为它们允许存在未观察到的异质性问题。异质性问题可能由于多种因素引起,如遗传倾向、环境因素或生活方式选择。脆弱性模型可以帮助识别这些因素,并更好地了解它们对生存的影响。在这项研究中,我们提出了一种新颖的拟 xgamma 脆弱性 (QXg-F) 模型,用于生存分析。在这项工作中,我们采用 Rao-Robson 和 Nikulin 检验来检验概率模型的有效性和适用性,研究了分布的性质,并将其性能与许多相关的 cox 脆弱性模型进行了比较。为了展示 QXg-F 模型如何很好地捕捉异质性并增强模型拟合度,我们使用模拟研究和真实数据应用,包括来自阿尔及利亚一家急诊医院的新数据集。根据我们的研究,QXg-F 模型是当前脆弱性建模分布的一种可行替代品,有可能提高许多不同领域(包括急诊护理)的生存分析的精度。此外,还通过不同的方法和应用于保险数据的模拟来研究新的 QXg-F 模型在保险中的能力和重要性。