The First Outpatient Department, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
ACS Biomater Sci Eng. 2024 May 13;10(5):2742-2761. doi: 10.1021/acsbiomaterials.4c00220. Epub 2024 Apr 19.
Periodontitis is a common condition characterized by a bacterial infection and the disruption of the body's immune-inflammatory response, which causes damage to the teeth and supporting tissues and eventually results in tooth loss. Current therapy involves the systemic and local administration of antibiotics. However, the existing treatments cannot exert effective, sustained release and maintain an effective therapeutic concentration of the drug at the lesion site. Hydrogels are used to treat periodontitis due to their low cytotoxicity, exceptional water retention capability, and controlled drug release profile. Hydrogels can imitate the extracellular matrix of periodontal cells while offering suitable sites to load antibiotics. This article reviews the utilization of hydrogels for periodontitis therapy based on the pathogenesis and clinical manifestations of the disease. Additionally, the latest therapeutic strategies for smart hydrogels and the main techniques for hydrogel preparation have been discussed. The information will aid in designing and preparing future hydrogels for periodontitis treatment.
牙周炎是一种常见的疾病，其特征是细菌感染和机体免疫炎症反应失调，导致牙齿和支持组织受损，最终导致牙齿脱落。目前的治疗方法包括全身和局部使用抗生素。然而，现有的治疗方法无法在病变部位发挥有效的、持续的释放作用，并维持药物的有效治疗浓度。水凝胶由于其低细胞毒性、出色的保水能力和可控的药物释放特性，被用于治疗牙周炎。水凝胶可以模拟牙周细胞的细胞外基质，同时为加载抗生素提供合适的部位。本文基于疾病的发病机制和临床表现，综述了水凝胶在牙周炎治疗中的应用。此外，还讨论了智能水凝胶的最新治疗策略和水凝胶制备的主要技术。这些信息将有助于设计和制备用于牙周炎治疗的未来水凝胶。
