Wang Yuxiao, Li Jiaxin, Tang Maomao, Peng Chengjun, Wang Guichun, Wang Jingjing, Wang Xinrui, Chang Xiangwei, Guo Jian, Gui Shuangying
Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China.
Department of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, Anhui 230012, China; Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application, Hefei, Anhui 230012, China; Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM), Hefei, Anhui 230012, China.
Biomed Pharmacother. 2023 Jun;162:114688. doi: 10.1016/j.biopha.2023.114688. Epub 2023 Apr 15.
Periodontitis is a chronic inflammatory disease initiated by pathogenic biofilms and host immunity that damages tooth-supporting tissues, including the gingiva, periodontal ligament and alveolar bone. The physiological functions of the oral cavity, such as saliva secretion and chewing, greatly reduce the residence of therapeutic drugs in the area of a periodontal lesion. In addition, complex and diverse pathogenic mechanisms make effectively treating periodontitis difficult. Therefore, designing advanced local drug delivery systems and rational therapeutic strategies are the basis for successful periodontitis treatment. Hydrogels have attracted considerable interest in the field of periodontitis treatment due to their biocompatibility, biodegradability and convenient administration to the periodontal pocket. In recent years, the focus of hydrogel research has shifted to smart stimuli-responsive hydrogels, which can undergo flexible sol-gel transitions in situ and control drug release in response to stimulation by temperature, light, pH, ROS, glucose, or enzymes. In this review, we systematically introduce the development and rational design of emerging smart stimuli-responsive hydrogels for periodontitis treatment. We also discuss the state-of-the-art therapeutic strategies of smart hydrogels based on the pathogenesis of periodontitis. Additionally, the challenges and future research directions of smart hydrogels for periodontitis treatment are discussed from the perspective of developing efficient hydrogel delivery systems and potential clinical applications.
牙周炎是一种由致病性生物膜和宿主免疫引发的慢性炎症性疾病，会损害牙齿支持组织，包括牙龈、牙周韧带和牙槽骨。口腔的生理功能，如唾液分泌和咀嚼，会大大减少治疗药物在牙周病变区域的停留时间。此外，复杂多样的致病机制使得有效治疗牙周炎变得困难。因此，设计先进的局部给药系统和合理的治疗策略是成功治疗牙周炎的基础。水凝胶因其生物相容性、生物可降解性以及便于向牙周袋给药等特点，在牙周炎治疗领域引起了广泛关注。近年来，水凝胶研究的重点已转向智能刺激响应性水凝胶，这种水凝胶能够在原位进行灵活的溶胶 - 凝胶转变，并根据温度、光、pH值、活性氧、葡萄糖或酶的刺激来控制药物释放。在这篇综述中，我们系统地介绍了用于牙周炎治疗的新型智能刺激响应性水凝胶的发展和合理设计。我们还基于牙周炎的发病机制讨论了智能水凝胶的最新治疗策略。此外，从开发高效水凝胶给药系统和潜在临床应用的角度，探讨了用于牙周炎治疗的智能水凝胶所面临的挑战和未来研究方向。
