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非糖尿病 ST 段抬高型心肌梗死患者三酰甘油-葡萄糖指数对左心室重构的预测价值。

Prognostic value of triglyceride-glucose index for left ventricular remodeling in nondiabetic ST-elevation myocardial infarction patients.

机构信息

Department of Cardiology, Etlik City Hospital, Ankara, Turkey.

出版信息

Biomark Med. 2024;18(6):243-252. doi: 10.2217/bmm-2024-0015. Epub 2024 Apr 19.

Abstract

The triglyceride-glucose (TyG) index is a marker of insulin resistance and is associated with cardiovascular mortality and morbidity. Left ventricular remodeling (LVR) after myocardial infarction (STEMI) is associated with poor prognosis. This retrospective study included 293 STEMI patients. Echocardiography was performed before discharge and 3 months after MI. Compared with the non-LVR group, TyG index value was found to be higher in the LVR group (p < 0.001). Logistic regression analysis showed that higher maximal troponin I value, higher calculated TyG index value, higher N-terminal prohormone of brain natriuretic peptide level and the presence of anterior MI were independently associated with the development of LVR. A high TyG index level may contribute to the prediction of LVR in nondiabetic STEMI patients undergoing successful primary percutaneous coronary intervention.

摘要

三酰甘油-葡萄糖(TyG)指数是胰岛素抵抗的标志物,与心血管死亡率和发病率有关。心肌梗死后的左心室重构(LVR)与不良预后相关。本回顾性研究纳入了 293 例急性 ST 段抬高型心肌梗死(STEMI)患者。在出院前和 MI 后 3 个月进行了超声心动图检查。与非 LVR 组相比,LVR 组的 TyG 指数值更高(p<0.001)。Logistic 回归分析显示,较高的最大肌钙蛋白 I 值、较高的计算 TyG 指数值、较高的脑钠肽前体 N 端水平以及前壁心肌梗死与 LVR 的发生独立相关。高 TyG 指数水平可能有助于预测成功接受经皮冠状动脉介入治疗的非糖尿病性 STEMI 患者的 LVR。

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