X-ray source motion blur modeling and deblurring with generative diffusion for digital breast tomosynthesis.

. Digital breast tomosynthesis (DBT) has significantly improved the diagnosis of breast cancer due to its high sensitivity and specificity in detecting breast lesions compared to two-dimensional mammography. However, one of the primary challenges in DBT is the image blur resulting from x-ray source motion, particularly in DBT systems with a source in continuous-motion mode. This motion-induced blur can degrade the spatial resolution of DBT images, potentially affecting the visibility of subtle lesions such as microcalcifications.. We addressed this issue by deriving an analytical in-plane source blur kernel for DBT images based on imaging geometry and proposing a post-processing image deblurring method with a generative diffusion model as an image prior.. We showed that the source blur could be approximated by a shift-invariant kernel over the DBT slice at a given height above the detector, and we validated the accuracy of our blur kernel modeling through simulation. We also demonstrated the ability of the diffusion model to generate realistic DBT images. The proposed deblurring method successfully enhanced spatial resolution when applied to DBT images reconstructed with detector blur and correlated noise modeling.. Our study demonstrated the advantages of modeling the imaging system components such as source motion blur for improving DBT image quality.