人类肿瘤抑制因子PDCD4直接与核糖体相互作用以抑制翻译。 - Suppr

Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

作者信息

Ye Xianwen, Huang Zixuan, Li Yi, Wang Mengjiao, Meng Wanyu, Miao Maojian, Cheng Jingdong

机构信息

Minhang Hospital & Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China.

出版信息

Cell Res. 2024 Jul;34(7):522-525. doi: 10.1038/s41422-024-00962-z. Epub 2024 Apr 19.

DOI:10.1038/s41422-024-00962-z

PMID:38641729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11217289/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dc8/11217289/c61ac1218371/41422_2024_962_Fig1_HTML.jpg

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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

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The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.

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Nucleic Acids Res. 2022 May 20;50(9):5282-5298. doi: 10.1093/nar/gkac283.

The space between notes: emerging roles for translationally silent ribosomes.

Trends Biochem Sci. 2022 Jun;47(6):477-491. doi: 10.1016/j.tibs.2022.02.003. Epub 2022 Mar 1.

The plasticity of mRNA translation during cancer progression and therapy resistance.

Nat Rev Cancer. 2021 Sep;21(9):558-577. doi: 10.1038/s41568-021-00380-y. Epub 2021 Aug 2.

A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.

EMBO J. 2021 Jan 4;40(1):e105179. doi: 10.15252/embj.2020105179. Epub 2020 Dec 8.

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Mol Cell. 2015 Aug 6;59(3):399-412. doi: 10.1016/j.molcel.2015.06.033. Epub 2015 Jul 23.

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Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3148-53. doi: 10.1073/pnas.0808275106. Epub 2009 Feb 9.

Structural basis for translational inhibition by the tumour suppressor Pdcd4.

EMBO J. 2009 Feb 4;28(3):274-85. doi: 10.1038/emboj.2008.278. Epub 2009 Jan 15.

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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

作者信息

Ye Xianwen, Huang Zixuan, Li Yi, Wang Mengjiao, Meng Wanyu, Miao Maojian, Cheng Jingdong

机构信息

出版信息

Cell Res. 2024 Jul;34(7):522-525. doi: 10.1038/s41422-024-00962-z. Epub 2024 Apr 19.

DOI:10.1038/s41422-024-00962-z

PMID:38641729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11217289/

Abstract

摘要

相似文献

Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

Cell Res. 2024 Jul;34(7):522-525. doi: 10.1038/s41422-024-00962-z. Epub 2024 Apr 19.

Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.

Mol Cell Biol. 2012 May;32(10):1818-29. doi: 10.1128/MCB.06317-11. Epub 2012 Mar 19.

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.

Nucleic Acids Res. 2014;42(17):11107-18. doi: 10.1093/nar/gku800. Epub 2014 Sep 4.

Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA.

Cell Death Differ. 2012 Apr;19(4):573-81. doi: 10.1038/cdd.2011.126. Epub 2011 Sep 30.

Programmed cell death 4 mechanism of action: The model to be updated?

Cell Cycle. 2017 Oct 2;16(19):1761-1764. doi: 10.1080/15384101.2017.1371881. Epub 2017 Aug 30.

PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.

Sci Rep. 2020 Feb 17;10(1):2758. doi: 10.1038/s41598-020-59678-w.

Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.

J Biol Chem. 2011 Dec 16;286(50):42855-62. doi: 10.1074/jbc.M111.269456. Epub 2011 Oct 27.

RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4.

Oncogene. 2016 Mar 31;35(13):1703-15. doi: 10.1038/onc.2015.235. Epub 2015 Jul 20.

Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.

Oncogene. 2017 Nov 9;36(45):6225-6234. doi: 10.1038/onc.2017.228. Epub 2017 Jul 10.

Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).

J Biol Chem. 2015 Feb 6;290(6):3468-87. doi: 10.1074/jbc.M114.631937. Epub 2014 Dec 17.

引用本文的文献

The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells.

Cell Death Discov. 2025 Jan 30;11(1):34. doi: 10.1038/s41420-025-02310-5.

The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance.

Pharmaceuticals (Basel). 2024 Oct 19;17(10):1396. doi: 10.3390/ph17101396.

Structural basis of AUC codon discrimination during translation initiation in yeast.

Nucleic Acids Res. 2024 Oct 14;52(18):11317-11335. doi: 10.1093/nar/gkae737.

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit.

Nat Commun. 2024 Aug 8;15(1):6633. doi: 10.1038/s41467-024-50672-8.

本文引用的文献

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.

Nat Struct Mol Biol. 2024 Mar;31(3):455-464. doi: 10.1038/s41594-023-01196-0. Epub 2024 Jan 29.

Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.

Nucleic Acids Res. 2022 May 20;50(9):5282-5298. doi: 10.1093/nar/gkac283.

The space between notes: emerging roles for translationally silent ribosomes.

Trends Biochem Sci. 2022 Jun;47(6):477-491. doi: 10.1016/j.tibs.2022.02.003. Epub 2022 Mar 1.

The plasticity of mRNA translation during cancer progression and therapy resistance.

Nat Rev Cancer. 2021 Sep;21(9):558-577. doi: 10.1038/s41568-021-00380-y. Epub 2021 Aug 2.

A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.

EMBO J. 2021 Jan 4;40(1):e105179. doi: 10.15252/embj.2020105179. Epub 2020 Dec 8.

Structure of a human 48 translational initiation complex.

Science. 2020 Sep 4;369(6508):1220-1227. doi: 10.1126/science.aba4904.

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex.

Mol Cell. 2015 Aug 6;59(3):399-412. doi: 10.1016/j.molcel.2015.06.033. Epub 2015 Jul 23.

Crystal structure of the eIF4A-PDCD4 complex.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3148-53. doi: 10.1073/pnas.0808275106. Epub 2009 Feb 9.

Structural basis for translational inhibition by the tumour suppressor Pdcd4.

EMBO J. 2009 Feb 4;28(3):274-85. doi: 10.1038/emboj.2008.278. Epub 2009 Jan 15.

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.

Science. 2006 Oct 20;314(5798):467-71. doi: 10.1126/science.1130276.

Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation.

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