Wang Qing, Yang Hsin-Sheng
Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA.
Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.
Pharmaceuticals (Basel). 2024 Oct 19;17(10):1396. doi: 10.3390/ph17101396.
Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.
程序性细胞死亡4（Pdcd4）是一种肿瘤抑制因子，已被证明能有效抑制肿瘤发生。在生物化学方面，Pdcd4与翻译起始因子4A结合并抑制蛋白质翻译。除了其在肿瘤抑制中的作用外，越来越多的证据表明Pdcd4可增强几种抗癌药物的化学敏感性。迄今为止，已鉴定出Pdcd4的众多翻译靶点。这些靶点控制着重要的信号转导途径，它们的减弱可能会提高化学敏感性或克服耐药性。本综述将讨论由Pdcd4调节的信号转导途径以及Pdcd4增强化学敏感性或对抗耐药性的潜在机制。
