Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Parana, Brazil.
Pharm Dev Technol. 2024 Jun;29(5):445-456. doi: 10.1080/10837450.2024.2345144. Epub 2024 Apr 25.
The digital light processing (DLP) printer has proven to be effective in biomedical and pharmaceutical applications, as its printing method does not induce shear and a strong temperature on the resin. In addition, the DLP printer has good resolution and print quality, which makes it possible to print complex structures with a customized shape, being used for various purposes ranging from jewelry application to biomedical and pharmaceutical areas. The big disadvantage of DLP is the lack of a biocompatible and non-toxic resin on the market. To overcome this limitation, an ideal resin for biomedical and pharmaceutical use is needed. The resin must have appropriate properties, so that the desired format is printed when with a determined wavelength is applied. Thus, the aim of this work is to bring the basic characteristics of the resins used by this printing method and the minimum requirements to start printing by DLP for pharmaceutical and biomedical applications. The DLP method has proven to be effective in obtaining pharmaceutical devices such as drug delivery systems. Furthermore, this technology allows the printing of devices of ideal size, shape and dosage, providing the patient with personalized treatment.
数字光处理（DLP）打印机已被证明在生物医学和制药应用中非常有效，因为其打印方法不会对树脂产生剪切力和强烈的温度。此外，DLP 打印机具有良好的分辨率和打印质量，使其能够打印具有定制形状的复杂结构，可用于从珠宝应用到生物医学和制药领域的各种用途。DLP 的一个大缺点是市场上缺乏生物相容性和无毒的树脂。为了克服这一限制，需要一种理想的用于生物医学和制药用途的树脂。该树脂必须具有适当的特性，以便在施加确定波长时打印出所需的格式。因此，本工作的目的是介绍该打印方法所使用的树脂的基本特性以及开始进行 DLP 打印的最低要求，适用于制药和生物医学应用。DLP 方法已被证明可有效获得药物输送系统等制药设备。此外，该技术允许打印理想尺寸、形状和剂量的设备，为患者提供个性化治疗。
