Department of Otolaryngology/Head and Neck Surgery, Louisiana Health Sciences Center, Shreveport, LA, 71103, USA.
Department of Otolaryngology/Head and Neck Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Adv Ther. 2024 Jun;41(6):2133-2150. doi: 10.1007/s12325-024-02861-6. Epub 2024 Apr 20.
Locally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.
A review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.
Studies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.
The management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.
局部晚期口腔癌（LAOCSCC）主要采用手术治疗，然后进行放疗联合或不联合化疗。
通过 Pubmed 检索文献，对报道局部晚期口腔癌治疗的研究进行综述。根据文献综述和该领域专家的意见，提出了建议。
研究表明，T4a 和低于下颌切迹（下颌切迹以下）的 T4b 切除后的结果相当。我们讨论了 LAOCSCC 分区切除术的概念以及颈部管理的问题。此外，拒绝或不能接受手术的患者可以采用放化疗，但疗效不确定。新辅助化疗在选择性患者中具有保留器官（下颌）的潜力。
LAOCSCC 的治疗策略应在多学科环境中确定，重点是肿瘤控制、功能保存和患者的生活质量。
