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骨骼肌结外自然杀伤/T 细胞淋巴瘤。

Extranodal natural killer/T cell lymphoma of the skeletal muscle.

机构信息

Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam Movement Sciences, Amsterdam, the Netherlands.

Department of Radiology, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20133, Milan, Italy.

出版信息

Skeletal Radiol. 2025 Jan;54(1):141-146. doi: 10.1007/s00256-024-04680-w. Epub 2024 Apr 20.

DOI:10.1007/s00256-024-04680-w
PMID:38642301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11573832/
Abstract

This case report highlights a case of extranodal NK/T cell lymphoma initially misdiagnosed as myositis, emphasizing the appearance on both MRI and FDG PET images. The patient presented with systemic symptoms and calf muscle swelling, prompting imaging studies that revealed diffuse muscle involvement. Despite negative myositis markers and inconclusive biopsy, post-amputation findings confirmed lymphoma with EBV positivity. The appearance in both MRI and FDG PET complicated the diagnostic process, underscoring the importance of considering lymphoma in cases of muscle-related symptoms to prevent delays in appropriate management. This case contributes to the understanding of the diagnostic challenges associated with extranodal NK/T cell lymphoma and emphasizes the significance of peripheral band-like features in imaging studies.

摘要

本病例报告强调了一例最初误诊为肌炎的结外 NK/T 细胞淋巴瘤病例,重点介绍了 MRI 和 FDG PET 图像上的表现。该患者出现全身症状和小腿肌肉肿胀,促使进行影像学研究显示弥漫性肌肉受累。尽管肌炎标志物阴性且活检结果不确定,但截肢后的结果证实了 EBV 阳性的淋巴瘤。MRI 和 FDG PET 的表现使诊断过程复杂化,强调了在出现肌肉相关症状时考虑淋巴瘤的重要性,以避免延误适当的治疗。本病例有助于了解与结外 NK/T 细胞淋巴瘤相关的诊断挑战,并强调了影像学研究中周边带样特征的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/c385b9162cea/256_2024_4680_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/2ec273a9c476/256_2024_4680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/414c51afb56d/256_2024_4680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/aa0f2d329f05/256_2024_4680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/ad5fc23f4bc9/256_2024_4680_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/c385b9162cea/256_2024_4680_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/2ec273a9c476/256_2024_4680_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/414c51afb56d/256_2024_4680_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/aa0f2d329f05/256_2024_4680_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/ad5fc23f4bc9/256_2024_4680_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/11573832/c385b9162cea/256_2024_4680_Fig5_HTML.jpg

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本文引用的文献

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Case report: Systemic muscle involvement as the primary clinical manifestation of chronic active Epstein-Barr virus infection: A case-based review.病例报告:以全身肌肉受累为主要临床表现的慢性活动性 EBV 感染:基于病例的综述。
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Muscular involvement of extranodal natural killer/T cell lymphoma misdiagnosed as polymyositis: A case report and review of literature.误诊为多发性肌炎的结外自然杀伤/T细胞淋巴瘤的肌肉受累:一例报告并文献复习
World J Clin Cases. 2020 Mar 6;8(5):963-970. doi: 10.12998/wjcc.v8.i5.963.
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Extranodal NK/T-cell Lymphoma Mimicking Granulomatous Myositis.
模仿肉芽肿性肌炎的结外NK/T细胞淋巴瘤
Intern Med. 2019 Jan 15;58(2):277-282. doi: 10.2169/internalmedicine.0859-18. Epub 2018 Aug 24.
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Primary skeletal muscle diffuse large B cell lymphoma: A case report and review of the literature.原发性骨骼肌弥漫性大B细胞淋巴瘤:一例报告并文献复习
Oncol Lett. 2015 Oct;10(4):2156-2160. doi: 10.3892/ol.2015.3505. Epub 2015 Jul 17.
5
CD30 extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.模仿脓性肌炎的CD30结外自然杀伤/T细胞淋巴瘤:一例报告
Oncol Lett. 2014 May;7(5):1419-1421. doi: 10.3892/ol.2014.1924. Epub 2014 Feb 28.
6
Unusual case of metachronous EBV-associated B-cell and NK/T-cell lymphoma mimicking polymyositis-diagnostic challenges and pitfalls.异时性EB病毒相关B细胞和NK/T细胞淋巴瘤酷似多发性肌炎的罕见病例——诊断挑战与陷阱
Am J Hematol. 2014 Jan;89(1):110-3. doi: 10.1002/ajh.23572. Epub 2013 Oct 15.
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MRI features of skeletal muscle lymphoma.骨骼肌淋巴瘤的 MRI 特征。
AJR Am J Roentgenol. 2010 Dec;195(6):1355-60. doi: 10.2214/AJR.09.3904.
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