前列环素在创伤性休克中的有益作用。
Beneficial actions of prostacyclin in traumatic shock.
作者信息
Lefer A M, Sollott S L, Galvin M J
出版信息
Prostaglandins. 1979 May;17(5):761-7. doi: 10.1016/s0090-6980(79)80048-9.
Prostacyclin (PGI2) infused at a rate of 350 ng/kg/min significantly increased survival time in rats subjected to Noble-Collip drug trauma from 2.7 +/- 0.3 to 4.6 +/- 0.2 h (p less than 0.01) compared with traumatized rats given only the vehicle (Tris buffer). Moreover, PGI2 treated rats exhibited significantly lower circulating cathepsin D and myocardial depressant factor (MDF) activities, indicative of lower lysosomal disruption and lower toxic factor formation. PGI2 induced vasodilation in rats as well as these other protective effects.
以350纳克/千克/分钟的速率输注前列环素（PGI2），可使遭受诺布尔-科利普药物损伤的大鼠存活时间显著延长，从2.7±0.3小时延长至4.6±0.2小时（p<0.01），与仅给予赋形剂（Tris缓冲液）的创伤大鼠相比。此外，PGI2处理的大鼠循环组织蛋白酶D和心肌抑制因子（MDF）活性显著降低，表明溶酶体破坏程度较低且毒性因子形成较少。PGI2可诱导大鼠血管舒张以及产生这些其他保护作用。
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