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用于序列调控低聚硫酸盐的迭代SuFEx方法及其向周期性共聚物的扩展。

Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers.

作者信息

Kim Min Pyeong, Kayal Swatilekha, Hwang Chiwon, Bae Jonghoon, Kim Hyunseok, Hwang Dong Gyu, Jeon Min Ho, Seo Jeong Kon, Ahn Dowon, Lee Wonjoo, Seo Sangwon, Chun Joong-Hyun, Yu Youngchang, Hong Sung You

机构信息

Department of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.

Center for Advanced Specialty Chemicals, Korea Research Institute of Chemical Technology (KRICT), Ulsan, 44412, Republic of Korea.

出版信息

Nat Commun. 2024 Apr 20;15(1):3381. doi: 10.1038/s41467-024-47567-z.

DOI:10.1038/s41467-024-47567-z
PMID:38643182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11032359/
Abstract

The synthesis of sequence-regulated oligosulfates has not yet been established due to the difficulties in precise reactivity control. In this work, we report an example of a multi-directional divergent iterative method to furnish oligosulfates based on a chain homologation approach, in which the fluorosulfate unit is regenerated. The oligosulfate sequences are determined by high resolution mass spectrometry of the hydrolyzed fragments, and polysulfate periodic copolymers are synthesized by using oligomeric bisfluorosulfates in a bi-directional fashion. The synthetic utility of this iterative ligation is demonstrated by preparing crosslinked network polymers as synthetic adhesive materials.

摘要

由于精确控制反应活性存在困难，序列调控的低聚硫酸盐的合成尚未实现。在这项工作中，我们报道了一个基于链同系化方法的多向发散迭代法制备低聚硫酸盐的例子，其中氟硫酸酯单元得以再生。低聚硫酸盐序列通过水解片段的高分辨率质谱测定，并且使用低聚双氟硫酸酯以双向方式合成了多硫酸盐周期性共聚物。通过制备交联网络聚合物作为合成粘合剂材料，证明了这种迭代连接的合成效用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/233b0d0e3246/41467_2024_47567_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/c80ad0b68711/41467_2024_47567_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/48c302bbca49/41467_2024_47567_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/f0fd1b63edc9/41467_2024_47567_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/2c4862dbd76f/41467_2024_47567_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/13f46f28071f/41467_2024_47567_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/233b0d0e3246/41467_2024_47567_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/c80ad0b68711/41467_2024_47567_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/48c302bbca49/41467_2024_47567_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/f0fd1b63edc9/41467_2024_47567_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/2c4862dbd76f/41467_2024_47567_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/13f46f28071f/41467_2024_47567_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/deef/11032359/233b0d0e3246/41467_2024_47567_Fig6_HTML.jpg

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本文引用的文献

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The Certainty of a Few Good Reactions.少数良好反应的确定性
Chem. 2023 Aug 10;9(8):2063-2077. doi: 10.1016/j.chempr.2023.03.017. Epub 2023 Apr 19.
2
Sulfur fluoride exchange.硫氟交换
Nat Rev Methods Primers. 2023;3. Epub 2023 Aug 3.
3
C-SuFEx linkage of sulfonimidoyl fluorides and organotrifluoroborates.磺酰亚胺基氟化物与有机三氟硼酸盐的碳-硫氟交换连接。
Nat Commun. 2024 Jan 25;15(1):727. doi: 10.1038/s41467-024-44998-6.
4
Functional Polythioamides Derived from Thiocarbonyl Fluoride.源自硫代羰基氟化物的功能性聚硫酰胺
Angew Chem Int Ed Engl. 2023 Nov 6;62(45):e202313779. doi: 10.1002/anie.202313779. Epub 2023 Oct 6.
5
Backbone Engineering of Monodisperse Conjugated Polymers via Integrated Iterative Binomial Synthesis.通过集成迭代二项式合成实现单分散共轭聚合物的主链工程
J Am Chem Soc. 2023 Aug 30;145(34):19120-19128. doi: 10.1021/jacs.3c08143. Epub 2023 Aug 21.
6
Synthesis of oligosaccharides to identify an immunologically active epitope against infection.合成寡糖以鉴定针对感染的免疫活性表位。
Chem Sci. 2023 Jun 23;14(27):7559-7563. doi: 10.1039/d3sc01242e. eCollection 2023 Jul 12.
7
Advances in the construction of diverse SuFEx linkers.多样化的硫氟交换（SuFEx）连接子构建方面的进展。
Natl Sci Rev. 2023 Apr 29;10(6):nwad123. doi: 10.1093/nsr/nwad123. eCollection 2023 Jun.
8
Iterative Synthesis of Oligosilanes Using Methoxyphenyl- or Hydrogen-Substituted Silylboronates as Building Blocks: A General Synthetic Method for Complex Oligosilanes.以甲氧基苯基或氢取代的硅硼酸酯为结构单元迭代合成低聚硅烷：一种合成复杂低聚硅烷的通用方法。
J Am Chem Soc. 2023 Jul 26;145(29):16249-16260. doi: 10.1021/jacs.3c05385. Epub 2023 Jul 12.
9
Synthesis of a glycan hairpin.聚糖发夹的合成。
Nat Chem. 2023 Oct;15(10):1461-1469. doi: 10.1038/s41557-023-01255-5. Epub 2023 Jul 3.
10
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Nat Rev Chem. 2022 Feb;6(2):146-162. doi: 10.1038/s41570-021-00352-8. Epub 2022 Jan 19.