Department of Urology, Affiliated Hospital of Qingdao University, Qingdao, China.
School of Basic Medicine, Qingdao University, Qingdao, China.
Thromb Res. 2024 Jun;238:19-26. doi: 10.1016/j.thromres.2024.04.014. Epub 2024 Apr 16.
Platelets, anucleate blood cells derive from megakaryocytes, are involved in cardiovascular diseases and tumors. FcγRIIA, the only FcγR expressed on human platelets, is known for its role in immune-related diseases. A growing body of evidence reveals that platelet FcγRIIA is a potential target for the prevention and control of cardiovascular disease and cancer, and is an advantageous biomarker. In this review, we describe the structure and physiological function of platelet FcγRIIA, its regulatory role in cardiovascular disease and cancer, and its potential clinical application.
血小板是无核血细胞，来源于巨核细胞，参与心血管疾病和肿瘤的发生。FcγRIIA 是人类血小板上唯一表达的 FcγR，已知其在免疫相关疾病中发挥作用。越来越多的证据表明，血小板 FcγRIIA 是预防和控制心血管疾病和癌症的潜在靶点，也是一种有利的生物标志物。在这篇综述中，我们描述了血小板 FcγRIIA 的结构和生理功能，及其在心血管疾病和癌症中的调节作用，以及其潜在的临床应用。
