Liu Jingwei, Du Jinyao, Zhang Lin-Bao, Li Ming, Guo Weisi
College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
J Org Chem. 2024 May 3;89(9):6465-6473. doi: 10.1021/acs.joc.4c00502. Epub 2024 Apr 21.
An electrochemical protocol for benzylic C(sp)-H aminopyridylation via direct C-H/N-H cross-coupling of alkylarenes with -aminopyridinium triflate has been developed. This method features excellent site-selectivity, broad substrate scope, redox reagent-free and facile scalability. The generated benzylaminopyridiniums can be readily converted to benzylamines via electroreductive N-N bond cleavage.
通过烷基芳烃与三氟甲磺酸 - 氨基吡啶鎓的直接C-H/N-H交叉偶联实现苄基C(sp)-H氨基吡啶化的电化学方法已经开发出来。该方法具有出色的位点选择性、广泛的底物范围、无需氧化还原试剂且易于扩大规模。生成的苄基氨基吡啶鎓可通过电还原N-N键断裂轻松转化为苄胺。
