Department of Microbiology, School of Pharmacy, Kitasato University, Tokyo, Japan.
Microbiol Immunol. 2024 Jun;68(6):206-211. doi: 10.1111/1348-0421.13128. Epub 2024 Apr 21.
Colonization resistance, conferred by the host's microbiota through both direct and indirect protective actions, serves to protect the host from enteric infections. Here, we identified the specific members of the gut microbiota that impact gastrointestinal colonization by Citrobacter rodentium, a murine pathogen causing colonic crypt hyperplasia. The gut colonization levels of C. rodentium in C57BL/6 mice varied among breeding facilities, probably due to differences in microbiota composition. A comprehensive analysis of the microbiota revealed that specific members of the microbiota may influence gut colonization by C. rodentium, thus providing a potential link between the two.
定植抗力是宿主的微生物群落通过直接和间接的保护作用赋予宿主的，用于保护宿主免受肠道感染。在这里，我们确定了肠道微生物群落的特定成员，这些成员影响柠檬酸杆菌的胃肠道定植，柠檬酸杆菌是一种导致结肠隐窝增生的鼠病原体。C57BL/6 小鼠中的柠檬酸杆菌在不同的繁殖设施中的肠道定植水平存在差异，这可能是由于微生物群落组成的差异。对微生物群落的综合分析表明，微生物群落的特定成员可能会影响柠檬酸杆菌的肠道定植，从而为两者之间提供了潜在的联系。
