Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
J Gerontol A Biol Sci Med Sci. 2024 Jul 1;79(7). doi: 10.1093/gerona/glae107.
Inhaled air pollutants (AirP) comprise extraordinarily diverse particles, volatiles, and gases from traffic, wildfire, cigarette smoke, dust, and various other sources. These pollutants contain numerous toxic components, which collectively differ in relative levels of components, but broadly share chemical classes. Exposure and health outcomes from AirP are complex, depending on pollutant source, duration of exposure, and socioeconomic status. We discuss examples in the current literature on organ responses to AirP, with a focus on lung, arteries, and brain. Some transcriptional responses are shared. It is well accepted that AirP contributes to Alzheimer's disease and other neurodegenerative conditions in the Gero-Exposome. However, we do not know which chemical compounds initiate these changes and how activation of these transcriptional pathways is further modified by genetics and prenatal development.
吸入性空气污染物（AirP）包括来自交通、野火、香烟烟雾、灰尘和其他各种来源的极其多样的颗粒、挥发物和气体。这些污染物含有许多有毒成分，它们在成分的相对水平上有所不同，但在化学类别上广泛共享。AirP 的暴露和健康后果很复杂，取决于污染物来源、暴露时间和社会经济地位。我们讨论了当前文献中关于器官对 AirP 反应的例子，重点是肺、动脉和大脑。一些转录反应是共享的。人们普遍认为，AirP 导致了老年暴露组中的阿尔茨海默病和其他神经退行性疾病。然而，我们不知道是哪些化学化合物引发了这些变化，以及这些转录途径的激活如何进一步受到遗传和产前发育的影响。
