First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China.
School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, China.
Int J Rheum Dis. 2024 Apr;27(4):e15147. doi: 10.1111/1756-185X.15147.
Gout is a chronic metabolic and immune disease, and its specific pathogenesis is still unclear. When the serum uric acid exceeds its saturation in the blood or tissue fluid, it is converted to monosodium urate crystals, which lead to acute arthritis of varying degrees, urinary stones, or irreversible peripheral joint damage, and in severe cases, impairment of vital organ function. Gout flare is a clinically significant state of acute inflammation in gout. The current treatment is mostly anti-inflammatory analgesics, which have numerous side effects with limited treatment methods. Gout pathogenesis involves many aspects. Therefore, exploring gout pathogenesis from multiple perspectives is conducive to identifying more therapeutic targets and providing safer and more effective alternative treatment options for patients with gout flare. Thus, this article is of great significance for further exploring the pathogenesis of gout. The author summarizes the pathogenesis of gout from four aspects: signaling pathways, inflammatory factors, intestinal flora, and programmed cell death, focusing on exploring more new therapeutic targets.
痛风是一种慢性代谢和免疫性疾病，其具体发病机制尚不清楚。当血清尿酸超过血液或组织液中的饱和度时，会转化为单钠尿酸盐晶体，导致不同程度的急性关节炎、尿路结石或不可逆转的外周关节损伤，严重时还会损害重要器官的功能。痛风发作是痛风的一种具有临床意义的急性炎症状态。目前的治疗方法大多是抗炎镇痛药，但治疗方法有限，且有许多副作用。痛风的发病机制涉及多个方面。因此，从多个角度探讨痛风的发病机制有助于发现更多的治疗靶点，为痛风发作患者提供更安全、更有效的替代治疗选择。因此，本文对进一步探讨痛风的发病机制具有重要意义。作者从信号通路、炎症因子、肠道菌群和细胞程序性死亡四个方面总结了痛风的发病机制，重点探讨了更多新的治疗靶点。
