Pootheri Aswathi, Lopez Wilner Martinez, Saraswathy Radha
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Genetics Department, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318, 11600, Montevideo, Uruguay.
Heliyon. 2024 Apr 13;10(8):e29270. doi: 10.1016/j.heliyon.2024.e29270. eCollection 2024 Apr 30.
Asthma is a chronic airway hyperresponsiveness disorder and Obese people have greater rates of asthma incidence and prevalence. Obesity, a complex condition, can cause nutritional metabolic problems that change trace elements and minerals. Trace element and antioxidant levels affect asthma aetiology. In this study, we aim to determine the serum levels of trace elements Zn, Fe, Cu, Mg, Co, Ni, Pb, Cd, and Cr, total antioxidants (TAS), and lifestyle that determine specific clinical conditions in asthma and obesity patients from Vellore City (Tamil Nadu, India).
A case-control study to determine the level of the serum trace elements with 838 subjects (n = 242 asthma patients, n = 140 asthmatic obese, n = 185 obese patients, and n = 271 controls) between the ages of 20 and 60 years was carried out. Asthma was diagnosed based on the clinical examination and pulmonary function tests. Trace element levels were determined by atomic absorption spectrophotometry (AAS) in serum, and a DPPH-free radical scavenging assay was used to determine the total antioxidant capacity level in serum.
In asthma male patients, serum levels of Zn, Fe, Cu, Mg, and TAS were significantly lower and Pb, Cd, and Cr significantly higher, whereas in female asthma patients, serum levels of Zn, Fe, Mg, and TAS were significantly lower and Pb significantly higher. In asthmatic obese male patients, Fe, Cu, and TAS were significantly lower, and Pb, Cd, and Co were significantly higher; in asthmatic obese female patients, Zn, Fe, Cu, Mg, and TAS were significantly lower, and Ni was significantly higher. In obese male patients, Zn, Fe, Cu, and TAS were significantly lower and Cd was significantly higher, and in obese female patients, Zn, Fe, Cu, Mg, and TAS were significantly lower.
The influence of the level of trace elements, heavy metal, total antioxidant, and the lifestyle patterns, may increase the risk of asthma and obesity.
哮喘是一种慢性气道高反应性疾病，肥胖人群的哮喘发病率和患病率更高。肥胖是一种复杂的状况，可导致营养代谢问题，进而改变微量元素和矿物质。微量元素和抗氧化剂水平会影响哮喘的病因。在本研究中，我们旨在测定印度泰米尔纳德邦韦洛尔市哮喘和肥胖患者血清中锌（Zn）、铁（Fe）、铜（Cu）、镁（Mg）、钴（Co）、镍（Ni）、铅（Pb）、镉（Cd）和铬（Cr）等微量元素、总抗氧化剂（TAS）水平以及决定特定临床状况的生活方式。
开展了一项病例对照研究，以测定838名年龄在20至60岁之间的受试者（n = 242名哮喘患者、n = 140名肥胖哮喘患者、n = 185名肥胖患者和n = 271名对照）血清中微量元素的水平。哮喘通过临床检查和肺功能测试进行诊断。血清中的微量元素水平通过原子吸收分光光度法（AAS）测定，采用DPPH自由基清除试验来测定血清中的总抗氧化能力水平。
在男性哮喘患者中，血清锌、铁、铜、镁和总抗氧化剂水平显著降低，铅、镉和铬水平显著升高；而在女性哮喘患者中，血清锌、铁、镁和总抗氧化剂水平显著降低且铅水平显著升高。在肥胖哮喘男性患者中，铁、铜和总抗氧化剂水平显著降低，铅、镉和钴水平显著升高；在肥胖哮喘女性患者中，锌、铁、铜、镁和总抗氧化剂水平显著降低且镍水平显著升高。在肥胖男性患者中，锌、铁、铜和总抗氧化剂水平显著降低且镉水平显著升高，在肥胖女性患者中，锌、铁、铜、镁和总抗氧化剂水平显著降低。
微量元素、重金属、总抗氧化剂水平以及生活方式模式的影响可能会增加哮喘和肥胖的风险。
