Al Shammaa AlMaha, Al-Thani Amna, Al-Kaabi Maryam, Al-Saeed Kaltham, Alanazi Maria, Shi Zumin
Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Diabetes Metab Syndr Obes. 2023 Jan 12;16:95-104. doi: 10.2147/DMSO.S391369. eCollection 2023.
Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration.
The study included 1000 adults aged 20 years and above who attended the Qatar Biobank Study (QBB) between 2012 and 2019. Body adiposity was assessed using dual-energy X-ray absorptiometry (DEXA). Serum magnesium concentration was measured. Sub-optimal magnesium was defined as magnesium concentration less than 0.85 mmol/L. The association was examined using linear regression.
The mean age of the participants (n=1000) was 35.8 (SD 10.3) years. More than half of the participants had sub-optimal magnesium concentrations (60.2% in men and 52.3% in women). Serum magnesium was inversely associated with different types of fat mass. In the fully adjusted model, per 1 SD increment of serum magnesium had standardized regression coefficients of -0.09 (p 0.005) for total fat mass, -0.08 (p 0.008) for trunk fat, -0.09 (p 0.003) for gynoid fat and -0.08 (p 0.008) for android fat. There was no gender difference in the association. The inverse association between serum magnesium and fat mass was significant in those with sleep duration ≥7 hours but not in those <7 hours. Depressive symptom and sleep did not mediate the association between serum magnesium and fat mass. Serum magnesium was inversely associated with metabolic syndrome (per 1 SD increment had an odds ratio (OR) of 0.70 (95% CI 0.57-0.85)).
There was an inverse association between serum magnesium and fat mass, especially among those with an adequate sleep duration and without chronic conditions including diabetes, hypertension and depression.
镁对于维持正常生理功能至关重要。我们旨在确定卡塔尔成年人血清镁与不同身体肥胖指标之间的关联。我们假设这种关联是由抑郁和睡眠时间介导的。
该研究纳入了1000名年龄在20岁及以上的成年人，他们在2012年至2019年期间参加了卡塔尔生物样本库研究（QBB）。使用双能X线吸收法（DEXA）评估身体肥胖情况。测量血清镁浓度。血清镁水平未达最佳状态被定义为镁浓度低于0.85 mmol/L。使用线性回归分析这种关联。
参与者（n = 1000）的平均年龄为35.8（标准差10.3）岁。超过一半的参与者血清镁浓度未达最佳状态（男性为60.2%，女性为52.3%）。血清镁与不同类型的脂肪量呈负相关。在完全调整模型中，血清镁每增加1个标准差，总脂肪量的标准化回归系数为 -0.09（p < 0.005），躯干脂肪为 -0.08（p < 0.008），臀部脂肪为 -0.09（p < 0.003），腹部脂肪为 -0.08（p < 0.008）。这种关联不存在性别差异。血清镁与脂肪量之间的负相关在睡眠时间≥7小时的人群中显著，但在睡眠时间<7小时的人群中不显著。抑郁症状和睡眠并未介导血清镁与脂肪量之间的关联。血清镁与代谢综合征呈负相关（每增加1个标准差，比值比（OR）为0.70（95%可信区间0.57 - 0.85））。
血清镁与脂肪量之间存在负相关，尤其是在睡眠时间充足且没有包括糖尿病、高血压和抑郁在内的慢性疾病的人群中。
