Department of Epidemiology and Biostatistics, College of Public Health, Temple University, 1301 Cecil B. Moore Ave, Philadelphia, PA, 19122, USA.
Department of Environmental Medicine, University of Rochester Medical Center, University of Rochester, 601 Elmwood Ave, Rochester, NY, 14642, USA.
Environ Health Prev Med. 2021 Nov 12;26(1):108. doi: 10.1186/s12199-021-01033-0.
The USA has a high burden of childhood asthma. Previous studies have observed associations between higher blood lead levels and greater hypersensitivity in children. The objective of the present study was to estimate the association between blood lead concentrations during early childhood and an asthma diagnosis between 48 and 72 months of age amongst a cohort with well-characterized blood lead concentrations. Blood lead concentrations were measured at 6, 12, 18, 24, 36, and 48 months of age in 222 children. The presence of an asthma diagnosis between 48 and 72 months was assessed using a questionnaire which asked parents or guardians whether they had been told by a physician, in the past 12 months, that their child had asthma. Crude and adjusted risk ratios (RR) of an asthma diagnosis were estimated for several parameterizations of blood lead exposure including lifetime average (6 to 48 months) and infancy average (6 to 24 months) concentrations. After adjustment for child sex, birthweight, daycare attendance, maternal race, education, parity, breastfeeding, income, and household smoking, age-specific or composite measures of blood lead were not associated with asthma diagnosis by 72 months of age in this cohort.
美国儿童哮喘负担沉重。既往研究观察到儿童血铅水平升高与过敏反应增加之间存在关联。本研究旨在评估在具有明确血铅浓度的队列中，儿童早期血铅浓度与 48 至 72 个月期间哮喘诊断之间的关系。在 222 名儿童中，分别在 6、12、18、24、36 和 48 个月时测量血铅浓度。通过问卷评估 48 至 72 个月期间是否存在哮喘诊断，问卷询问父母或监护人在过去 12 个月中是否被医生告知其孩子患有哮喘。对于包括终生平均（6 至 48 个月）和婴儿期平均（6 至 24 个月）浓度在内的几种血铅暴露参数化，估计了哮喘诊断的粗风险比（RR）和调整风险比（RR）。在校正了儿童性别、出生体重、日托出勤率、母亲种族、教育程度、产次、母乳喂养、收入和家庭吸烟状况后，在该队列中，特定年龄或综合血铅指标与 72 个月时的哮喘诊断无关。
