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作者信息

Neira-Carrillo Andrónico, Zegers Arce Tatiana, Yazdani-Pedram Mehrdad

机构信息

Department of Biological and Animal Science, Faculty of Veterinary and Animal Sciences, Universidad de Chile, Santa Rosa 11735, La Pintana, Santiago 1025000, Chile.

Department of Organic and Physical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile, Olivos 1007, Independencia, Santiago 8380492, Chile.

出版信息

ACS Omega. 2024 Apr 6;9(15):17045-17053. doi: 10.1021/acsomega.3c08736. eCollection 2024 Apr 16.

DOI:10.1021/acsomega.3c08736
PMID:38645337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11024939/
Abstract

Calcium oxalate (CaOx) is known to grow on organic matrices and is often associated with the formation of kidney stones. Therefore, it is crucial to understand the nucleation and growth mechanisms. This study investigates the role of electrospun polycaprolactone (PCL)-loaded zarzaparrilla (ZP) () in the electrocrystallization (EC) of CaOx. Electrospinning (ES) was used to prepare PCL meshes with random (R) and aligned (A) fiber orientations. CaOx particles were grown directly on conductive tin indium oxide (ITO) glass modified with electrospun ZP-loaded PCL meshes by EC. The CaOx crystals after EC were measured by chronopotentiometry (CP), optical microscopy (OM), scanning electron microscopy (SEM), and X-ray diffraction (XRD), which showed that the ZP additive and PCL fiber orientations are key factors for CaOx nucleation.

摘要

已知草酸钙（CaOx）在有机基质上生长，且常与肾结石的形成有关。因此，了解其成核和生长机制至关重要。本研究调查了电纺载有土茯苓（ZP）的聚己内酯（PCL）在CaOx电结晶（EC）中的作用。采用静电纺丝（ES）制备了具有随机（R）和取向（A）纤维取向的PCL网。通过EC将CaOx颗粒直接生长在用电纺载ZP的PCL网改性的导电氧化铟锡（ITO）玻璃上。通过计时电位法（CP）、光学显微镜（OM）、扫描电子显微镜（SEM）和X射线衍射（XRD）对EC后的CaOx晶体进行了测量，结果表明ZP添加剂和PCL纤维取向是CaOx成核的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/54016ec1e147/ao3c08736_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/ba1501b828f0/ao3c08736_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/0953ced24b7b/ao3c08736_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/738d5bbcb3ec/ao3c08736_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/02ed89ba8ac7/ao3c08736_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/54016ec1e147/ao3c08736_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/ba1501b828f0/ao3c08736_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/0953ced24b7b/ao3c08736_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/738d5bbcb3ec/ao3c08736_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/02ed89ba8ac7/ao3c08736_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5d1/11024939/54016ec1e147/ao3c08736_0005.jpg

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Himalayan Citrus jambhiri juice reduced renal crystallization in nephrolithiasis by possible inhibition of glycolate oxidase and matrix metalloproteinases.喜马拉雅酸橙果汁可能通过抑制乙醇酸氧化酶和基质金属蛋白酶来减少肾结石中的肾结晶。
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In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats.
骆驼蓬及其主要生物碱对乙二醇诱导的大鼠尿路结石抑制作用的体内研究
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Electrocrystallization of Calcium Oxalate on Electrospun PCL Fibers Loaded with Phytic Acid as a Template.以植酸为模板负载于电纺聚己内酯纤维上的草酸钙电结晶
Polymers (Basel). 2022 Aug 5;14(15):3190. doi: 10.3390/polym14153190.
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