Ligler F S, Brodsky I, Schlam M L, Fuscaldo K E
Cancer Detect Prev. 1985;8(1-2):317-23.
Twenty-eight patients with chronic myelocytic leukemia (CML) and the Philadelphia chromosome (Ph1) were monitored using cytofluorometry and cytogenetics. During chronic phase, abnormal populations could be detected using commercially available monoclonal antibodies. These abnormal populations fell into two categories based on the presence or absence of HLA.DR. Patients with HLA.DR+ abnormal cells showed no clonal evolution and progressed to lymphoid blast crisis. Patients with HLA.DR- abnormal cells exhibited chromosomal abnormalities in addition to the Ph1 and progressed to a myeloblastic acute phase.
使用细胞荧光测定法和细胞遗传学对28例患有慢性粒细胞白血病（CML）和费城染色体（Ph1）的患者进行了监测。在慢性期，使用市售单克隆抗体可检测到异常细胞群。根据是否存在HLA-DR，这些异常细胞群分为两类。带有HLA-DR+异常细胞的患者未出现克隆进化，而是进展为淋巴细胞母细胞危象。带有HLA-DR-异常细胞的患者除了有Ph1外，还表现出染色体异常，并进展为粒细胞急性白血病期。
