Margulis M S, Zhuravliov S J, Andereiman L A
Resuscitation. 1979;7(1):45-57. doi: 10.1016/0300-9572(79)90014-5.
The efficacy of heterotopic liver transplantation to support life and to correct metabolic disturbances in the presence of acute hepatic failure was tested in 70 dogs. Acute hepatic failure was induced by two-stage ischaemic damage to the animals' livers and by biliary obstruction. The donor liver was stored for 3 h by the method of intermittent perfusion. The graft was placed in the right paravertebral gutter. The inflow was arterial only. No immunosuppressive agents were administered. During the postoperative period the main biochemical indices decreased and returned to almost normal values by the fourth day. The auxiliary liver was able to correct the clotting of blood. There was significant regression of encephalopathy, which was confirmed by encephalographic monitoring. Special attention was paid to the adaptation of the stored graft after revascularization. Resuscitation from hepatic failure and subsequent survival of transplanted animals confirmed the significant therapeutic effect of heterotopic allotransplant.
在70只犬身上测试了异位肝移植在急性肝衰竭情况下维持生命和纠正代谢紊乱的疗效。通过对动物肝脏进行两阶段缺血性损伤和胆道梗阻诱导急性肝衰竭。供肝采用间歇性灌注法保存3小时。移植物置于右椎旁沟。仅进行动脉血流灌注。未给予免疫抑制剂。术后主要生化指标下降，并在第四天恢复至几乎正常水平。辅助肝脏能够纠正血液凝固。脑病有明显消退，脑电图监测证实了这一点。特别关注了再灌注后保存移植物的适应性。肝衰竭复苏及移植动物随后的存活证实了异位同种异体移植具有显著的治疗效果。
