Diaz A, Ricco J B, Franco D, Gigou M, Szekely A M, Bismuth H
Arch Surg. 1977 Jan;112(1):74-8. doi: 10.1001/archsurg.1977.01370010076015.
The ability of a heterotopic graft to prolong life in animals dying in hepatic coma due to liver necrosis has never been definitely established. Acute hepatic failure was produced in 15 dogs by an hour of total interruption of the hepatic blood supply. Nine dogs received an intrathoracic hepatic homograft concurrently. Nontransplanted dogs died within 21 hours in hepatic coma, while transplanted dogs survived significantly longer (P less than .001). In all transplanted dogs, biological signs of hepatic failure were corrected in 24 hours. In four animals, the graft was removed on the fifth postoperative day. Two of those survived for 10 and 15 days respectively with normal hepatic function. These results demonstrate that a temporary heterotopic liver transplant is able to support life during the acute, normally lethal phase in dogs with massive liver necrosis.
异位移植延长因肝坏死而死于肝昏迷的动物生命的能力尚未得到明确证实。通过完全阻断肝血流1小时，在15只狗身上制造了急性肝衰竭。9只狗同时接受了胸腔内肝同种异体移植。未移植的狗在21小时内死于肝昏迷，而移植的狗存活时间明显更长（P小于0.001）。在所有接受移植的狗中，肝衰竭的生物学体征在24小时内得到纠正。在4只动物中，术后第5天移除了移植物。其中2只分别存活了10天和15天，肝功能正常。这些结果表明，临时异位肝移植能够在患有大面积肝坏死的狗的急性、通常致命阶段维持生命。
