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用于下尿路功能障碍的不断发展的阴部神经调节类型。

Evolving types of pudendal neuromodulation for lower urinary tract dysfunction.

作者信息

Parodi Stefano, Kendall Harry J, Terrone Carlo, Heesakkers John Pfa

机构信息

Department of Urology, IRCCS, Ospedale Policlinico San Martino, Genova, Italy.

Department of Urology, Maastricht University Medical Centre, Maastricht, the Netherlands.

出版信息

Cent European J Urol. 2024;77(1):82-88. doi: 10.5173/ceju.2023.86. Epub 2024 Jan 6.

Abstract

INTRODUCTION

Sacral neuromodulation and posterior tibial nerve stimulation for lower urinary tract dysfunction (LUTD) and overactive bladder yield good and reliable results. However, neuromodulation research is continuously evolving because there is still need for more patient-friendly treatment options in the therapeutic management of LUTD. Pudendal neuromodulation (PNM) has been emerging as a promising alternative treatment option for the last few decades. The aim of this study is to review the current state of the art of PNM.

MATERIAL AND METHODS

A wide literature search was conducted in the field of PNM using Medline through the PubMed database and Elsevier using the Scopus database; a critical review of the results was then carried out. PNM has been studied in its various possible aspects: percutaneous PNM, transrectal/transvaginal PNM, and both percutaneous and transcutaneous dorsal genital nerve stimulation.

RESULTS

Each technique was found to result in promising improvements in different clinical outcomes, with some trials reporting even better results than sacral neuromodulation.

CONCLUSIONS

As a result of a comparison between the various PNM techniques with both sacral neuromodulation and posterior tibial nerve stimulation, we think that PNM should be seen as seriously promising, and we believe it will expand the treatment options for overactive bladder. Even though several studies accordingly showed PNM to be safe and effective, a systematic review and meta-analysis were not feasible. PNM in its various techniques is a promising treatment for LUTD. Nevertheless, further research is needed to include it in treatment algorithms.

摘要

引言

骶神经调节和胫后神经刺激治疗下尿路功能障碍(LUTD)和膀胱过度活动症可产生良好且可靠的效果。然而,神经调节研究仍在不断发展,因为在LUTD的治疗管理中仍需要更多对患者友好的治疗选择。在过去几十年中,阴部神经调节(PNM)已成为一种有前景的替代治疗选择。本研究的目的是综述PNM的当前技术水平。

材料与方法

通过PubMed数据库在Medline中以及通过Scopus数据库在爱思唯尔中对PNM领域进行了广泛的文献检索;然后对结果进行了批判性综述。PNM已在其各个可能的方面进行了研究:经皮PNM、经直肠/经阴道PNM以及经皮和经皮背侧生殖神经刺激。

结果

发现每种技术在不同的临床结局方面都有有前景的改善,一些试验报告的结果甚至比骶神经调节更好。

结论

通过将各种PNM技术与骶神经调节和胫后神经刺激进行比较,我们认为PNM应被视为非常有前景的,并且我们相信它将扩大膀胱过度活动症的治疗选择。尽管有几项研究相应地表明PNM是安全有效的,但系统评价和荟萃分析并不可行。各种技术的PNM对LUTD是一种有前景的治疗方法。然而,需要进一步研究以将其纳入治疗方案。

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