Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 23 Arabi, Yaman Street, Velenjak, P.O.Code: 1985717413, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arch Gynecol Obstet. 2023 Nov;308(5):1555-1566. doi: 10.1007/s00404-023-07132-3. Epub 2023 Jul 9.
Hyperandrogenic intrauterine environment may lead to the development of metabolic disorders in offspring in their later life. In this study, we aimed to determine the impact of maternal hyperandrogenism (MHA) on metabolic syndrome (MetS) risk in female offspring in their later life.
In this cohort study conducted in Tehran, Iran, female offspring with MHA (n = 323) and without MHA (controls) (n = 1125) were selected. Both groups of female offspring were followed from the baseline to the date of the incidence of events, censoring, or end of the study period, whichever came first. We used age-scaled unadjusted and adjusted Cox regression models to assess the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between MHA and MetS in female offspring. The software package STATA was used for statistical analysis, and the significance level was set at P < 0.05.
We observed a higher risk of MetS (unadjusted HR (95% CI), 1.36 (1.05-1.77)), (P = 0.02) and (adjusted HR (95% CI), 1.34 (1.00-1.80)), (P = 0.05, borderline)), in female offspring with MHA, compared to controls. The results were adjusted for the potential confounders including body mass index (BMI) at baseline, net changes of BMI, physical activity, education status, and birth weight.
Our results suggest that MHA increases the risk of developing MetS in female offspring in their later life. Screening of these female offspring for MetS may be recommended.
高雄激素宫内环境可能导致后代在以后的生活中出现代谢紊乱。在这项研究中，我们旨在确定母体高雄激素血症（MHA）对后代以后发生代谢综合征（MetS）风险的影响。
本队列研究在伊朗德黑兰进行，选择了高雄激素血症的女性后代（MHA）（n=323）和无高雄激素血症的对照组（n=1125）。两组女性后代均从基线随访至事件发生、删失或研究期结束的日期，以先到者为准。我们使用年龄调整的未调整和调整后的 Cox 回归模型评估 MHA 与女性后代 MetS 之间的关联的风险比（HR）和 95%置信区间（CI）。使用 STATA 软件包进行统计分析，显著性水平设为 P<0.05。
我们观察到 MHA 女性后代发生 MetS 的风险较高（未调整 HR（95%CI），1.36（1.05-1.77）），（P=0.02）和（调整 HR（95%CI），1.34（1.00-1.80）），（P=0.05，边缘）），与对照组相比。结果调整了潜在混杂因素，包括基线时的体重指数（BMI）、BMI 的净变化、体力活动、教育状况和出生体重。
我们的研究结果表明，MHA 增加了女性后代以后发生 MetS 的风险。可能建议对这些女性后代进行 MetS 筛查。
