Wang Qian, Liu Jianfang, Guo Yikun, Dong Guanzhong, Zou Wenying, Chen Zhuoyou
Department of Neurology, the Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Braz J Med Biol Res. 2019;52(8):e8443. doi: 10.1590/1414-431X20198443. Epub 2019 Jul 29.
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cognitive processes, and cognitive impairment in Parkinson's disease (PD), but with contradictory findings. Thus, this meta-analysis was performed to clarify the possible association. Relevant studies were identified by a systematic search of PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases. The strength of the association was evaluated using crude odds ratios and 95% confidence interval. Finally, six studies involving 532 cases and 802 controls were included. Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cognitive impairment in PD, especially in Caucasian populations. In conclusion, BDNF G196A (Val66Met) is confirmed to be a risk factor for cognitive impairment in PD.
脑源性神经营养因子（BDNF）在中枢神经系统中广泛表达，并能延长黑质中多巴胺能神经元的存活时间。最近有几项研究调查了影响认知过程的单核苷酸多态性BDNF G196A（Val66Met）与帕金森病（PD）认知障碍之间的关联，但结果相互矛盾。因此，进行了这项荟萃分析以阐明可能的关联。通过系统检索PubMed、Embase和中国知网（CNKI）数据库来识别相关研究。使用粗比值比和95%置信区间评估关联强度。最后，纳入了六项研究，共涉及532例病例和802例对照。我们的分析表明，G196A（Val66Met）多态性与PD的认知障碍显著相关，尤其是在白种人群中。总之，BDNF G196A（Val66Met）被证实是PD认知障碍的一个危险因素。
