Department of Neurology, The Fifth Central Hospital of Tianjin, 40 Zhe jiang Road of Binhai New Area, Tianjin, 300450, People's Republic of China.
Department of Neurology, The People's Hospital of Yichun City, Yichun University, 88 West Zhong Shan Road, Yichun, Jiangxi Province, 336000, People's Republic of China.
Neurol Sci. 2019 Sep;40(9):1901-1907. doi: 10.1007/s10072-019-03907-2. Epub 2019 May 18.
Conflicting results identifying the association between Brain-derived neurotrophic factor (BDNF) polymorphism, Val66Met, and cognitive impairment in Parkinson's disease (PD) have been reported.
To clarify whether Val66Met is related to cognitive impairment in PD, we carried out this meta-analysis by searching literature from PubMed, Web of Science, and Embase databases regarding this polymorphism. Six eligible studies involving 1467 PD patients were included in this meta-analysis. Our results showed statistically significant association between Val66Met and risk of cognitive impairment in PD patients in additive model (Met/Met vs. Val/Val: OR 3.82, 95%CI 1.32 to 11.08, p = 0.01) and recessive model (Met/Met vs. Val-carrier: OR 3.81, 95%CI 1.38 to 10.53, p = 0.01) except for dominant model.
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
脑源性神经营养因子（BDNF）基因 Val66Met 多态性与帕金森病（PD）认知障碍的相关性存在争议。
为了明确 Val66Met 是否与 PD 患者的认知障碍有关，我们通过检索 PubMed、Web of Science 和 Embase 数据库中的相关文献，进行了这项荟萃分析。这项荟萃分析纳入了 6 项符合条件的研究，共纳入 1467 名 PD 患者。我们的结果显示，在相加模型中（Met/Met 与 Val/Val：OR 3.82，95%CI 1.32 至 11.08，p=0.01）和隐性模型中（Met/Met 与 Val 携带者：OR 3.81，95%CI 1.38 至 10.53，p=0.01），Val66MetBDNF 多态性与 PD 患者认知障碍的风险存在统计学显著关联，但在显性模型中无此关联。
本荟萃分析提示 Val66MetBDNF 多态性可能与帕金森病认知障碍有关，但由于研究数量有限，还需要进行设计更好、样本量更大的研究来验证这些结果。
Zotero 插件